Artificial Control of Cell Signaling Using a Photocleavable Cobalt(III)-Nitrosyl Complex

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Cells use gaseous molecules such as nitric oxide (NO) to transmit both intracellular and intercellular signals. In principle, the endogenous small molecules regulate physiological changes, but it is unclear how randomly diffusive molecules trigger and discriminate signaling programs. Herein, it is shown that gasotransmitters use time-dependent dynamics to discriminate the endogenous and exogenous inputs. For a real-time stimulation of cell signaling, we synthesized a photo-cleavable metal-nitrosyl complex, [Co-III(MDAP)(NO)(CH3CN)](2+) (MDAP=N,N '-dimethyl-2,11-diaza[3,3](2,6)pyridinophane), which can stably deliver and selectively release NO with fine temporal resolution in the cytosol, and used this to study the extracellular signal-regulated kinases (ERKs), revealing how cells use both exogenous and endogenous NO to disentangle cellular responses. This technique can be to understand how diverse cellular signaling networks are dynamically interconnected and also to control drug delivery systems.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2019-07
Language
English
Article Type
Article
Citation

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.58, no.30, pp.10126 - 10131

ISSN
1433-7851
DOI
10.1002/anie.201903106
URI
http://hdl.handle.net/10203/263994
Appears in Collection
CH-Journal Papers(저널논문)
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