Heterogeneous Sequences of Brain Cytoplasmic 200 RNA Formed by Multiple Adenine Nucleotide Insertions

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Brain cytoplasmic 200 RNA (BC200 RNA), originally identified as a neuron-specific non-coding RNA, is also observed in various cancer cells that originate from non-neural cells. Studies have revealed diverse functions of BC200 RNA in cancer cells. Accordingly, we hypothesized that BC200 RNA might be modified in cancer cells to generate cancerous BC200 RNA responsible for its cancer-specific functions. Here, we report that BC200 RNA sequences are highly heterogeneous in cancer cells by virtue of multiple adenine nucleotide insertions in the internal A-rich region. The insertion of adenine nucleotides enhances BC200 RNA-mediated translation inhibition, possibly by increasing the binding affinity of BC200 RNA for eIF4A (eukaryotic translation initiation factor 4A).
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Issue Date
2019-06
Language
English
Article Type
Article
Citation

MOLECULES AND CELLS, v.42, no.6, pp.495 - 500

ISSN
1016-8478
DOI
10.14348/molcells.2019.0108
URI
http://hdl.handle.net/10203/263314
Appears in Collection
CH-Journal Papers(저널논문)
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