Non-Coding RNAs in Caenorhabditis elegans Aging

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Non-coding RNAs (ncRNAs) comprise various RNA species, including small ncRNAs and long ncRNAs (lncRNAs). ncRNAs regulate various cellular processes, including transcription and translation of target messenger RNAs. Recent studies also indicate that ncRNAs affect organismal aging and conversely aging influences ncRNA levels. In this review, we discuss our current understanding of the roles of ncRNAs in aging and longevity, focusing on recent advances using the roundworm Caenorhabditis elegans. Expression of various ncRNAs, including microRNA (miRNA), tRNA-derived small RNA (tsRNA), ribosomal RNA (rRNA), PIWI-interacting RNA (piRNA), circular RNA (circRNA), and lncRNA, is altered during aging in C. elegans. Genetic modulation of specific ncRNAs affects longevity and aging rates by modulating established aging-regulating protein factors. Because many aging-regulating mechanisms in C. elegans are evolutionarily conserved, these studies will provide key information regarding how ncRNAs modulate aging and lifespan in complex organisms, including mammals.
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Issue Date
2019-05
Language
English
Article Type
Review
Citation

MOLECULES AND CELLS, v.42, no.5, pp.379 - 385

ISSN
1016-8478
DOI
10.14348/molcells.2019.0077
URI
http://hdl.handle.net/10203/262618
Appears in Collection
BS-Journal Papers(저널논문)
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