Roles of Primary Cilia in the Developing Brain

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Essential to development, primary cilia are microtubule-based cellular organelles that protrude from the surface of cells. Acting as cellular antenna, primary cilia play central roles in transducing or regulating several signaling pathways, including Sonic hedgehog (Shh) and Wnt signaling. Defects in primary cilia contribute to a group of syndromic disorders known as "ciliopathies" and can adversely affect development of the brain and other essential organs, including the kidneys, eyes, and liver. The molecular mechanisms of how defective primary cilia contribute to neurological defects, however, remain poorly understood. In this mini review, we summarize recent advances in understanding of the interactions between primary cilia and signaling pathways essential to cellular homeostasis and brain development.
Publisher
FRONTIERS MEDIA SA
Issue Date
2019-05
Language
English
Article Type
Review
Citation

FRONTIERS IN CELLULAR NEUROSCIENCE, v.13

ISSN
1662-5102
DOI
10.3389/fncel.2019.00218
URI
http://hdl.handle.net/10203/262446
Appears in Collection
MSE-Journal Papers(저널논문)
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