Induced pluripotent stem cell model for cardiofaciocutaneous syndrome and uses thereofcardiofaciocutaneous 신드롬을 위한 유발된 전분화능 줄기세포 모델과 그 용도

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dc.contributor.authorHan, Yong-Mahnko
dc.contributor.authorHan, Kyu-Minko
dc.date.accessioned2019-04-29T07:33:08Z-
dc.date.available2019-04-29T07:33:08Z-
dc.date.issued2019-01-08-
dc.identifier.urihttp://hdl.handle.net/10203/261628-
dc.description.abstractThe present invention relates to an induced pluripotent stem cell (iPS) model for cardiofaciocutaneous (CFC) syndrome, a method for producing the model, and uses of the iPS model in the analysis of neural development in CFC syndrome. Specifically, the CFC syndrome-derived iPS and generation and differentiation of an embryonic body were induced from the fibroblasts of a CFC syndrome patient, and the CFC syndrome-derived iPS and embryonic body were confirmed to exhibit broken embryonic body shapes and no differentiation into neurons. When a CFC syndrome-derived embryonic body was induced by treating with p-ERK and p-SMAD1 inhibitors, the embryonic body exhibited a normal embryonic body shape and effectively differentiated into neurons. Thus, the CFC syndrome patient-derived stem cell model of the invention can be effectively used in the research for neural development in cardiofaciocutaneous syndrome.-
dc.titleInduced pluripotent stem cell model for cardiofaciocutaneous syndrome and uses thereof-
dc.title.alternativecardiofaciocutaneous 신드롬을 위한 유발된 전분화능 줄기세포 모델과 그 용도-
dc.typePatent-
dc.type.rimsPAT-
dc.contributor.localauthorHan, Yong-Mahn-
dc.contributor.assigneeKAIST-
dc.identifier.iprsType특허-
dc.identifier.patentApplicationNumber15103271-
dc.identifier.patentRegistrationNumber10174288-
dc.date.application2013-12-11-
dc.date.registration2019-01-08-
dc.publisher.countryUS-
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BS-Patent(특허)
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