DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Yong-Mahn | ko |
dc.contributor.author | Han, Kyu-Min | ko |
dc.date.accessioned | 2019-04-29T07:33:08Z | - |
dc.date.available | 2019-04-29T07:33:08Z | - |
dc.date.issued | 2019-01-08 | - |
dc.identifier.uri | http://hdl.handle.net/10203/261628 | - |
dc.description.abstract | The present invention relates to an induced pluripotent stem cell (iPS) model for cardiofaciocutaneous (CFC) syndrome, a method for producing the model, and uses of the iPS model in the analysis of neural development in CFC syndrome. Specifically, the CFC syndrome-derived iPS and generation and differentiation of an embryonic body were induced from the fibroblasts of a CFC syndrome patient, and the CFC syndrome-derived iPS and embryonic body were confirmed to exhibit broken embryonic body shapes and no differentiation into neurons. When a CFC syndrome-derived embryonic body was induced by treating with p-ERK and p-SMAD1 inhibitors, the embryonic body exhibited a normal embryonic body shape and effectively differentiated into neurons. Thus, the CFC syndrome patient-derived stem cell model of the invention can be effectively used in the research for neural development in cardiofaciocutaneous syndrome. | - |
dc.title | Induced pluripotent stem cell model for cardiofaciocutaneous syndrome and uses thereof | - |
dc.title.alternative | cardiofaciocutaneous 신드롬을 위한 유발된 전분화능 줄기세포 모델과 그 용도 | - |
dc.type | Patent | - |
dc.type.rims | PAT | - |
dc.contributor.localauthor | Han, Yong-Mahn | - |
dc.contributor.assignee | KAIST | - |
dc.identifier.iprsType | 특허 | - |
dc.identifier.patentApplicationNumber | 15103271 | - |
dc.identifier.patentRegistrationNumber | 10174288 | - |
dc.date.application | 2013-12-11 | - |
dc.date.registration | 2019-01-08 | - |
dc.publisher.country | US | - |
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