Objectives. To fully realize the range of indication and clinical advantages of the new multi-layered zirconias, a comprehensive understanding of their chemical composition, microstructure, low temperature degradation (LTD) resistance, and translucency properties is paramount. Methods. A zirconia system (Katana, Kuraray Noritake), including 3 distinct grades of multi-layered zirconias, was selected for study: Ultra Translucent Multi-layered zirconia (UTML), Super Translucent Multi-layered zirconia (STML), and Multi-layered zirconia (ML). For different materials and their individual layers, the chemical composition, zirconia phase fractions, and microstructure were determined by X-ray fluorescence (XRF), X-ray diffraction (XRD), and field emission scanning electron microscopy (FE-SEM). Also, their resistance to LTD and translucency properties were characterized. Results. Our findings revealed no major differences amongst layers, but the 3 materials were very distinct-UTML: 5Y-PSZ (5 mol% yttria-partially-stabilized zirconia) with (7) over tilde5 wt% cubic content and a 4.05 (+/- 0.85)iim average grain size, STML: 4Y-PSZ with (6) over tilde5 wt% cubic content and a 2.81 (+/- 0.17) mu m average grain size, and ML: 3Y-PSZ with <50 wt% cubic content and a 0.63 (+0.03) mu m average grain size. After water aging at 120 degrees C for 12 h, greater monoclinic content was found in ML. UTML and STML did not show detectable monoclinic phase. The translucency was similar among layers, and also between UTML and STML, which were superior to ML. Significance. For each multi-layered zirconia grades, the layers are only differed in pigment types and contents, which yield remarkably natural shade gradients. Also, despite the significant compositional difference between STML and UTML, both materials showed similar translucencies. (C) 2019 The Academy of Dental Materials. Published by Elsevier Inc. All rights reserved.