A new class of constitutively active super-enhancers is associated with fast recovery of 3D chromatin loops

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dc.contributor.authorRyu, Jayoungko
dc.contributor.authorKim, Hyunwoongko
dc.contributor.authorYang, Dongchanko
dc.contributor.authorLee, Andrew J.ko
dc.contributor.author정인경ko
dc.date.accessioned2019-04-18T00:50:04Z-
dc.date.available2019-04-18T00:50:04Z-
dc.date.created2019-04-16-
dc.date.created2019-04-16-
dc.date.created2019-04-16-
dc.date.issued2019-03-
dc.identifier.citationBMC BIOINFORMATICS, v.20-
dc.identifier.issn1471-2105-
dc.identifier.urihttp://hdl.handle.net/10203/260999-
dc.description.abstractBackgroundSuper-enhancers or stretch enhancers are clusters of active enhancers that often coordinate cell-type specific gene regulation during development and differentiation. In addition, the enrichment of disease-associated single nucleotide polymorphism in super-enhancers indicates their critical function in disease-specific gene regulation. However, little is known about the function of super-enhancers beyond gene regulation.ResultsIn this study, through a comprehensive analysis of super-enhancers in 30 human cell/tissue types, we identified a new class of super-enhancers which are constitutively active across most cell/tissue types. These common' super-enhancers are associated with universally highly expressed genes in contrast to the canonical definition of super-enhancers that assert cell-type specific gene regulation. In addition, the genome sequence of these super-enhancers is highly conserved by evolution and among humans, advocating their universal function in genome regulation. Integrative analysis of 3D chromatin loops demonstrates that, in comparison to the cell-type specific super-enhancers, the cell-type common super-enhancers present a striking association with rapidly recovering loops.ConclusionsIn this study, we propose that a new class of super-enhancers may play an important role in the early establishment of 3D chromatin structure.-
dc.languageEnglish-
dc.publisherBMC-
dc.titleA new class of constitutively active super-enhancers is associated with fast recovery of 3D chromatin loops-
dc.typeArticle-
dc.identifier.wosid000462857100003-
dc.identifier.scopusid2-s2.0-85063802744-
dc.type.rimsART-
dc.citation.volume20-
dc.citation.publicationnameBMC BIOINFORMATICS-
dc.identifier.doi10.1186/s12859-019-2646-3-
dc.contributor.localauthor정인경-
dc.contributor.nonIdAuthorRyu, Jayoung-
dc.contributor.nonIdAuthorKim, Hyunwoong-
dc.contributor.nonIdAuthorLee, Andrew J.-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle; Proceedings Paper-
dc.subject.keywordAuthorSuper-enhancer-
dc.subject.keywordAuthorGene regulation-
dc.subject.keywordAuthor3D chromatin structure-
dc.subject.keywordAuthorChromatin loops-
dc.subject.keywordPlusINTEGRATIVE ANALYSIS-
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