DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ryu, Jayoung | ko |
dc.contributor.author | Kim, Hyunwoong | ko |
dc.contributor.author | Yang, Dongchan | ko |
dc.contributor.author | Lee, Andrew J. | ko |
dc.contributor.author | 정인경 | ko |
dc.date.accessioned | 2019-04-18T00:50:04Z | - |
dc.date.available | 2019-04-18T00:50:04Z | - |
dc.date.created | 2019-04-16 | - |
dc.date.created | 2019-04-16 | - |
dc.date.created | 2019-04-16 | - |
dc.date.issued | 2019-03 | - |
dc.identifier.citation | BMC BIOINFORMATICS, v.20 | - |
dc.identifier.issn | 1471-2105 | - |
dc.identifier.uri | http://hdl.handle.net/10203/260999 | - |
dc.description.abstract | BackgroundSuper-enhancers or stretch enhancers are clusters of active enhancers that often coordinate cell-type specific gene regulation during development and differentiation. In addition, the enrichment of disease-associated single nucleotide polymorphism in super-enhancers indicates their critical function in disease-specific gene regulation. However, little is known about the function of super-enhancers beyond gene regulation.ResultsIn this study, through a comprehensive analysis of super-enhancers in 30 human cell/tissue types, we identified a new class of super-enhancers which are constitutively active across most cell/tissue types. These common' super-enhancers are associated with universally highly expressed genes in contrast to the canonical definition of super-enhancers that assert cell-type specific gene regulation. In addition, the genome sequence of these super-enhancers is highly conserved by evolution and among humans, advocating their universal function in genome regulation. Integrative analysis of 3D chromatin loops demonstrates that, in comparison to the cell-type specific super-enhancers, the cell-type common super-enhancers present a striking association with rapidly recovering loops.ConclusionsIn this study, we propose that a new class of super-enhancers may play an important role in the early establishment of 3D chromatin structure. | - |
dc.language | English | - |
dc.publisher | BMC | - |
dc.title | A new class of constitutively active super-enhancers is associated with fast recovery of 3D chromatin loops | - |
dc.type | Article | - |
dc.identifier.wosid | 000462857100003 | - |
dc.identifier.scopusid | 2-s2.0-85063802744 | - |
dc.type.rims | ART | - |
dc.citation.volume | 20 | - |
dc.citation.publicationname | BMC BIOINFORMATICS | - |
dc.identifier.doi | 10.1186/s12859-019-2646-3 | - |
dc.contributor.localauthor | 정인경 | - |
dc.contributor.nonIdAuthor | Ryu, Jayoung | - |
dc.contributor.nonIdAuthor | Kim, Hyunwoong | - |
dc.contributor.nonIdAuthor | Lee, Andrew J. | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article; Proceedings Paper | - |
dc.subject.keywordAuthor | Super-enhancer | - |
dc.subject.keywordAuthor | Gene regulation | - |
dc.subject.keywordAuthor | 3D chromatin structure | - |
dc.subject.keywordAuthor | Chromatin loops | - |
dc.subject.keywordPlus | INTEGRATIVE ANALYSIS | - |
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