In Vitro Reconstruction of Brain Tumor Microenvironment

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The cancer cells in brain tumors interact with their microenvironment, which includes stromal cells, the extracellular matrix (ECM), and the physical properties of tissues. The reciprocal interaction between cancer cells and the surrounding microenvironment regulates the biological behavior of cancer cells. To improve our understanding of the progression of brain tumors, it is useful to construct physiologically relevant brain tumor models. Consequently, versatile in vitro tumor models ranging from simplistic two-dimensional (2D) cultures to three-dimensional (3D) cultures have been developed to mimic the microenvironments of the brain. This review covers the recent progress in the in vitro reconstruction of brain tumor microenvironments.
Publisher
KOREAN BIOCHIP SOCIETY-KBCS
Issue Date
2019-03
Language
English
Article Type
Review
Citation

BIOCHIP JOURNAL, v.13, no.1, pp.1 - 7

ISSN
1976-0280
DOI
10.1007/s13206-018-3102-6
URI
http://hdl.handle.net/10203/260892
Appears in Collection
BiS-Journal Papers(저널논문)
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