Method for preparing endocrine aggregate of insulin-producing beta cells from human pluripotent stem cells인간 다분화능 줄기 세포로부터 인슐린 유발 베타 세포의 내분비의 집합체를 제조하기 위한 방법

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The present invention prepared insulin-producing endocrine cells by inducing the differentiation of human embryonic stem cells or human induced pluripotent stem cells into definitive endoderm (DE), pancreatic endoderm (PE), endocrine progenitors (EP), and endocrine cells (EC) stepwise in that order. Particularly, the present invention established the conditions for the formation of an insulin producing endocrine aggregate (EA) from the endocrine cells. Especially in this invention, it was confirmed that the endocrine aggregate has the cell proliferation potential at a significant level and has the increased insulin productivity as well as the activity of inhibiting cell necrosis and apoptosis. Therefore, the method for preparing the endocrine aggregate of insulin-producing beta cells from human pluripotent stem cells can be effectively used for the examination of the medicinal effect of the conventional antidiabetic agents and of the novel antidiabetic drugs.
Assignee
KAIST
Country
US (United States)
Issue Date
2018-06-05
Application Date
2014-08-07
Application Number
14453799
Registration Date
2018-06-05
Registration Number
9988605
URI
http://hdl.handle.net/10203/255791
Appears in Collection
BS-Patent(특허)
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