The present disclosure relates to a pre-5th-Generation (5G) or 5G communication system to be provided for supporting higher data rates beyond 4th-Generation (4G) communication system such as a Long Term Evolution (LTE). A method for controlling interference in a signal transmitting apparatus in a mobile communication system is provided. The method includes transmitting data to a first signal receiving apparatus using a plurality of channels; receiving information indicating whether at least one of the plurality of channels exists as an interference channel in a second signal receiving apparatus from the second signal receiving apparatus; receiving interference control information for controlling interference for the second signal receiving apparatus from the second signal receiving apparatus based on the received information, and generating interference control data based on the interference control information; and transmitting the interference control data to the first signal receiving apparatus.