AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic plasticity in Aplysia

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dc.contributor.authorLee, Yong-Seokko
dc.contributor.authorChoi, Sun-Limko
dc.contributor.authorJun, Heejungko
dc.contributor.authorYim, Se-Jeongko
dc.contributor.authorLee, Jin-Ako
dc.contributor.authorKim, Hyoung F.ko
dc.contributor.authorLee, Seung-Heeko
dc.contributor.authorShim, Jaehoonko
dc.contributor.authorLee, Kyungminko
dc.contributor.authorJang, Deok-Jinko
dc.contributor.authorKaang, Bong-Kiunko
dc.date.accessioned2019-04-15T15:51:46Z-
dc.date.available2019-04-15T15:51:46Z-
dc.date.created2013-09-13-
dc.date.issued2012-09-
dc.identifier.citationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.109, no.38, pp.15520 - 15525-
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10203/255333-
dc.description.abstractThe consolidation of long-term memory for sensitization and synaptic facilitation in Aplysia requires synthesis of new mRNA including the immediate early gene Aplysia CCAAT enhancer-binding protein (ApC/EBP). After the rapid induction of ApC/EBP expression in response to repeated treatments of 5-hydroxytryptamine (5-HT), ApC/EBP mRNA is temporarily expressed in sensory neurons of sensory-to-motor synapses. However, the molecular mechanism underlying the rapid degradation of ApC/EBP transcript is not known. Here, we cloned an AU-rich element (ARE)-binding protein, ApAUF1, which functions as a destabilizing factor for ApC/EBP mRNA. ApAUF1 was found to bind to the 3' UTR of ApC/EBP mRNA that contains AREs and subsequently reduces the expression of ApC/EBP 3' UTR-containing reporter genes. Moreover, overexpression of ApAUF1 inhibited the induction of ApC/EBP mRNA in sensory neurons and also impaired long-term facilitation of sensory-to-motor synapses by repetitive 5-HT treatments. These results provide evidence for a critical role of the posttranscriptional modification of ApC/EBP mRNA during the consolidation of synaptic plasticity.-
dc.languageEnglish-
dc.publisherNATL ACAD SCIENCES-
dc.subjectGENE-EXPRESSION-
dc.subjectPOSTTRANSCRIPTIONAL REGULATION-
dc.subjectSENSORY NEURONS-
dc.subjectMEMORY STORAGE-
dc.subjectUP-REGULATION-
dc.subjectFACILITATION-
dc.subjectDEGRADATION-
dc.subjectCPEB-
dc.subjectCONSOLIDATION-
dc.subjectISOFORMS-
dc.titleAU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic plasticity in Aplysia-
dc.typeArticle-
dc.identifier.wosid000309211000088-
dc.identifier.scopusid2-s2.0-84866544096-
dc.type.rimsART-
dc.citation.volume109-
dc.citation.issue38-
dc.citation.beginningpage15520-
dc.citation.endingpage15525-
dc.citation.publicationnamePROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-
dc.identifier.doi10.1073/pnas.1116224109-
dc.contributor.localauthorLee, Seung-Hee-
dc.contributor.nonIdAuthorLee, Yong-Seok-
dc.contributor.nonIdAuthorChoi, Sun-Lim-
dc.contributor.nonIdAuthorJun, Heejung-
dc.contributor.nonIdAuthorYim, Se-Jeong-
dc.contributor.nonIdAuthorLee, Jin-A-
dc.contributor.nonIdAuthorKim, Hyoung F.-
dc.contributor.nonIdAuthorShim, Jaehoon-
dc.contributor.nonIdAuthorLee, Kyungmin-
dc.contributor.nonIdAuthorJang, Deok-Jin-
dc.contributor.nonIdAuthorKaang, Bong-Kiun-
dc.type.journalArticleArticle-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusPOSTTRANSCRIPTIONAL REGULATION-
dc.subject.keywordPlusSENSORY NEURONS-
dc.subject.keywordPlusMEMORY STORAGE-
dc.subject.keywordPlusUP-REGULATION-
dc.subject.keywordPlusFACILITATION-
dc.subject.keywordPlusDEGRADATION-
dc.subject.keywordPlusCPEB-
dc.subject.keywordPlusCONSOLIDATION-
dc.subject.keywordPlusISOFORMS-
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