DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yong-Seok | ko |
dc.contributor.author | Choi, Sun-Lim | ko |
dc.contributor.author | Jun, Heejung | ko |
dc.contributor.author | Yim, Se-Jeong | ko |
dc.contributor.author | Lee, Jin-A | ko |
dc.contributor.author | Kim, Hyoung F. | ko |
dc.contributor.author | Lee, Seung-Hee | ko |
dc.contributor.author | Shim, Jaehoon | ko |
dc.contributor.author | Lee, Kyungmin | ko |
dc.contributor.author | Jang, Deok-Jin | ko |
dc.contributor.author | Kaang, Bong-Kiun | ko |
dc.date.accessioned | 2019-04-15T15:51:46Z | - |
dc.date.available | 2019-04-15T15:51:46Z | - |
dc.date.created | 2013-09-13 | - |
dc.date.created | 2013-09-13 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.109, no.38, pp.15520 - 15525 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/255333 | - |
dc.description.abstract | The consolidation of long-term memory for sensitization and synaptic facilitation in Aplysia requires synthesis of new mRNA including the immediate early gene Aplysia CCAAT enhancer-binding protein (ApC/EBP). After the rapid induction of ApC/EBP expression in response to repeated treatments of 5-hydroxytryptamine (5-HT), ApC/EBP mRNA is temporarily expressed in sensory neurons of sensory-to-motor synapses. However, the molecular mechanism underlying the rapid degradation of ApC/EBP transcript is not known. Here, we cloned an AU-rich element (ARE)-binding protein, ApAUF1, which functions as a destabilizing factor for ApC/EBP mRNA. ApAUF1 was found to bind to the 3' UTR of ApC/EBP mRNA that contains AREs and subsequently reduces the expression of ApC/EBP 3' UTR-containing reporter genes. Moreover, overexpression of ApAUF1 inhibited the induction of ApC/EBP mRNA in sensory neurons and also impaired long-term facilitation of sensory-to-motor synapses by repetitive 5-HT treatments. These results provide evidence for a critical role of the posttranscriptional modification of ApC/EBP mRNA during the consolidation of synaptic plasticity. | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | POSTTRANSCRIPTIONAL REGULATION | - |
dc.subject | SENSORY NEURONS | - |
dc.subject | MEMORY STORAGE | - |
dc.subject | UP-REGULATION | - |
dc.subject | FACILITATION | - |
dc.subject | DEGRADATION | - |
dc.subject | CPEB | - |
dc.subject | CONSOLIDATION | - |
dc.subject | ISOFORMS | - |
dc.title | AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic plasticity in Aplysia | - |
dc.type | Article | - |
dc.identifier.wosid | 000309211000088 | - |
dc.identifier.scopusid | 2-s2.0-84866544096 | - |
dc.type.rims | ART | - |
dc.citation.volume | 109 | - |
dc.citation.issue | 38 | - |
dc.citation.beginningpage | 15520 | - |
dc.citation.endingpage | 15525 | - |
dc.citation.publicationname | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.identifier.doi | 10.1073/pnas.1116224109 | - |
dc.contributor.localauthor | Lee, Seung-Hee | - |
dc.contributor.nonIdAuthor | Lee, Yong-Seok | - |
dc.contributor.nonIdAuthor | Choi, Sun-Lim | - |
dc.contributor.nonIdAuthor | Jun, Heejung | - |
dc.contributor.nonIdAuthor | Yim, Se-Jeong | - |
dc.contributor.nonIdAuthor | Lee, Jin-A | - |
dc.contributor.nonIdAuthor | Kim, Hyoung F. | - |
dc.contributor.nonIdAuthor | Shim, Jaehoon | - |
dc.contributor.nonIdAuthor | Lee, Kyungmin | - |
dc.contributor.nonIdAuthor | Jang, Deok-Jin | - |
dc.contributor.nonIdAuthor | Kaang, Bong-Kiun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | POSTTRANSCRIPTIONAL REGULATION | - |
dc.subject.keywordPlus | SENSORY NEURONS | - |
dc.subject.keywordPlus | MEMORY STORAGE | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | FACILITATION | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | CPEB | - |
dc.subject.keywordPlus | CONSOLIDATION | - |
dc.subject.keywordPlus | ISOFORMS | - |
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