Microfluidic dissociation and clearance of Alzheimer's beta-amyloid aggregates

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dc.contributor.authorLee, Joon Seokko
dc.contributor.authorPark, Chan Beumko
dc.date.accessioned2011-11-08T01:33:04Z-
dc.date.available2011-11-08T01:33:04Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2010-06-
dc.identifier.citationBIOMATERIALS, v.31, no.26, pp.6789 - 6795-
dc.identifier.issn0142-9612-
dc.identifier.urihttp://hdl.handle.net/10203/25503-
dc.description.abstractThe abnormal aggregation of beta-amyloid peptide (A beta) in the brain is a major histopathological feature of Alzheimer's disease. Herein, we first report on microfluidic dissociation and clearance analysis of preformed A beta aggregates for parallel screening of aggregate destabilizers. As a proof of the concept for the microfluidic platform, we investigated (1) microfluidics-based clearance of metal ion-induced A beta aggregates using different types of metal chelators, (2) the clearance effect of deferoxamine on A beta aggregates within microchannels, (3) comparison between destabilized A beta dissociated from pre-formed A beta aggregates and remaining deposits within the microchannels both before and after the clearance, and (4) secondary structure change in A beta deposits by the clearance treatment. The microfluidics-based clearance system should be suitable for efficient screening of chemical candidates to enhance the clearance of A beta deposits prior to their in vivo evaluation. (C) 2010 Elsevier Ltd. All rights reserved.-
dc.description.sponsorshipThis study was supported by the National Research Foundation (NRF) via National Research Laboratory (NRL) (R0A-2008-000- 20041-0), Converging Research Center (2009-0082276), and Engineering Research Center (2008-0062205) programs. This research was also partially supported by the BioGreen 21 program (20070301034038) and the Korea Research Foundation (KRF-2006- 331-D00113, KRF-2006-311-D00078), Republic of Korea.en
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherElsevier Sci Ltd-
dc.subjectHIGH-THROUGHPUT ANALYSIS-
dc.subjectFIBRIL FORMATION-
dc.subjectIN-VITRO-
dc.subjectDISEASE-
dc.subjectPEPTIDE-
dc.subjectDEPOSITION-
dc.subjectTOXICITY-
dc.subjectPATHWAYS-
dc.subjectALUMINUM-
dc.subjectTHERAPY-
dc.titleMicrofluidic dissociation and clearance of Alzheimer's beta-amyloid aggregates-
dc.typeArticle-
dc.identifier.wosid000280692500015-
dc.identifier.scopusid2-s2.0-77954384174-
dc.type.rimsART-
dc.citation.volume31-
dc.citation.issue26-
dc.citation.beginningpage6789-
dc.citation.endingpage6795-
dc.citation.publicationnameBIOMATERIALS-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorPark, Chan Beum-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorAmyloid-
dc.subject.keywordAuthorSelf-assembly-
dc.subject.keywordAuthorDissociation-
dc.subject.keywordAuthorMicrofluidics-
dc.subject.keywordAuthorMetal chelators-
dc.subject.keywordPlusHIGH-THROUGHPUT ANALYSIS-
dc.subject.keywordPlusFIBRIL FORMATION-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusPEPTIDE-
dc.subject.keywordPlusDEPOSITION-
dc.subject.keywordPlusTOXICITY-
dc.subject.keywordPlusPATHWAYS-
dc.subject.keywordPlusALUMINUM-
dc.subject.keywordPlusTHERAPY-
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