DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Joon Seok | ko |
dc.contributor.author | Park, Chan Beum | ko |
dc.date.accessioned | 2011-11-08T01:33:04Z | - |
dc.date.available | 2011-11-08T01:33:04Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010-06 | - |
dc.identifier.citation | BIOMATERIALS, v.31, no.26, pp.6789 - 6795 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | http://hdl.handle.net/10203/25503 | - |
dc.description.abstract | The abnormal aggregation of beta-amyloid peptide (A beta) in the brain is a major histopathological feature of Alzheimer's disease. Herein, we first report on microfluidic dissociation and clearance analysis of preformed A beta aggregates for parallel screening of aggregate destabilizers. As a proof of the concept for the microfluidic platform, we investigated (1) microfluidics-based clearance of metal ion-induced A beta aggregates using different types of metal chelators, (2) the clearance effect of deferoxamine on A beta aggregates within microchannels, (3) comparison between destabilized A beta dissociated from pre-formed A beta aggregates and remaining deposits within the microchannels both before and after the clearance, and (4) secondary structure change in A beta deposits by the clearance treatment. The microfluidics-based clearance system should be suitable for efficient screening of chemical candidates to enhance the clearance of A beta deposits prior to their in vivo evaluation. (C) 2010 Elsevier Ltd. All rights reserved. | - |
dc.description.sponsorship | This study was supported by the National Research Foundation (NRF) via National Research Laboratory (NRL) (R0A-2008-000- 20041-0), Converging Research Center (2009-0082276), and Engineering Research Center (2008-0062205) programs. This research was also partially supported by the BioGreen 21 program (20070301034038) and the Korea Research Foundation (KRF-2006- 331-D00113, KRF-2006-311-D00078), Republic of Korea. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | Elsevier Sci Ltd | - |
dc.subject | HIGH-THROUGHPUT ANALYSIS | - |
dc.subject | FIBRIL FORMATION | - |
dc.subject | IN-VITRO | - |
dc.subject | DISEASE | - |
dc.subject | PEPTIDE | - |
dc.subject | DEPOSITION | - |
dc.subject | TOXICITY | - |
dc.subject | PATHWAYS | - |
dc.subject | ALUMINUM | - |
dc.subject | THERAPY | - |
dc.title | Microfluidic dissociation and clearance of Alzheimer's beta-amyloid aggregates | - |
dc.type | Article | - |
dc.identifier.wosid | 000280692500015 | - |
dc.identifier.scopusid | 2-s2.0-77954384174 | - |
dc.type.rims | ART | - |
dc.citation.volume | 31 | - |
dc.citation.issue | 26 | - |
dc.citation.beginningpage | 6789 | - |
dc.citation.endingpage | 6795 | - |
dc.citation.publicationname | BIOMATERIALS | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Chan Beum | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Amyloid | - |
dc.subject.keywordAuthor | Self-assembly | - |
dc.subject.keywordAuthor | Dissociation | - |
dc.subject.keywordAuthor | Microfluidics | - |
dc.subject.keywordAuthor | Metal chelators | - |
dc.subject.keywordPlus | HIGH-THROUGHPUT ANALYSIS | - |
dc.subject.keywordPlus | FIBRIL FORMATION | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | DEPOSITION | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | ALUMINUM | - |
dc.subject.keywordPlus | THERAPY | - |
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