Thermally drawn fibers as nerve guidance scaffolds

Cited 52 time in webofscience Cited 48 time in scopus
  • Hit : 358
  • Download : 0
Synthetic neural scaffolds hold promise to eventually replace nerve autografts for tissue repair following peripheral nerve injury. Despite substantial evidence for the influence of scaffold geometry and dimensions on the rate of axonal growth, systematic evaluation of these parameters remains a challenge due to limitations in materials processing. We have employed fiber drawing to engineer a wide spectrum of polymer-based neural scaffolds with varied geometries and core sizes. Using isolated whole dorsal root ganglia as an in vitro model system we have identified key features enhancing nerve growth within these fiber scaffolds. Our approach enabled straightforward integration of microscopic topography at the scale of nerve fascicles within the scaffold cores, which led to accelerated Schwann cell migration, as well as neurite growth and alignment. Our findings indicate that fiber drawing provides a scalable and versatile strategy for producing nerve guidance channels capable of controlling direction and accelerating the rate of axonal growth. (C) 2015 Published by Elsevier Ltd.
Publisher
ELSEVIER SCI LTD
Issue Date
2016-03
Language
English
Article Type
Article
Citation

BIOMATERIALS, v.81, pp.27 - 35

ISSN
0142-9612
DOI
10.1016/j.biomaterials.2015.11.063
URI
http://hdl.handle.net/10203/254205
Appears in Collection
BiS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 52 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0