DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Daniel Youngsuk | ko |
dc.contributor.author | Hwang, Kyungmin | ko |
dc.contributor.author | Ahn, Jinhyo | ko |
dc.contributor.author | Seo, Yeong-Hyeon | ko |
dc.contributor.author | Kim, Jae-Beom | ko |
dc.contributor.author | Lee, Soyoung | ko |
dc.contributor.author | Yoon, Jin Hui | ko |
dc.contributor.author | Kong, Eunji | ko |
dc.contributor.author | Jeong, Yong | ko |
dc.contributor.author | Jon, Sangyong | ko |
dc.contributor.author | Kim, Pilhan | ko |
dc.contributor.author | Jeong, Ki-Hun | ko |
dc.date.accessioned | 2019-03-19T01:50:19Z | - |
dc.date.available | 2019-03-19T01:50:19Z | - |
dc.date.created | 2019-03-06 | - |
dc.date.created | 2019-03-06 | - |
dc.date.created | 2019-03-06 | - |
dc.date.created | 2019-03-06 | - |
dc.date.created | 2019-03-06 | - |
dc.date.created | 2019-03-06 | - |
dc.date.created | 2019-03-06 | - |
dc.date.issued | 2019-03 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v.9, pp.3560 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10203/251784 | - |
dc.description.abstract | An endomicroscope opens new frontiers of non-invasive biopsy for in vivo imaging applications. Here we report two-photon laser scanning endomicroscope for in vivo cellular and tissue imaging using a Lissajous fiber scanner. The fiber scanner consists of a piezoelectric (PZT) tube, a single double-clad fiber (DCF) with high fluorescence collection, and a micro-tethered-silicon-oscillator (MTSO) for the separation of biaxial resonant scanning frequencies. The endomicroscopic imaging exhibits 5 frames/s with 99% in scanning density by using the selection rule of scanning frequencies. The endomicroscopic scanner was compactly packaged within a stainless tube of 2.6 mm in diameter with a high NA gradient-index (GRIN) lens, which can be easily inserted into the working channel of a conventional laparoscope. The lateral and axial resolutions of the endomicroscope are 0.70 µm and 7.6 μm, respectively. Two-photon fluorescence images of a stained kidney section and miscellaneous ex vivo and in vivo organs from wild type and green fluorescent protein transgenic (GFP-TG) mice were successfully obtained by using the endomicroscope. The endomicroscope also obtained label free images including autofluorescence and second-harmonic generation of an ear tissue of Thy1-GCaMP6 (GP5.17) mouse. The Lissajous scanning two-photon endomicroscope can provide a compact handheld platform for in vivo tissue imaging or optical biopsy applications. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Lissajous Scanning Two-photon Endomicroscope for in vivo Tissue Imaging | - |
dc.type | Article | - |
dc.identifier.wosid | 000460381600133 | - |
dc.identifier.scopusid | 2-s2.0-85062586761 | - |
dc.type.rims | ART | - |
dc.citation.volume | 9 | - |
dc.citation.beginningpage | 3560 | - |
dc.citation.publicationname | SCIENTIFIC REPORTS | - |
dc.identifier.doi | 10.1038/s41598-019-38762-w | - |
dc.contributor.localauthor | Jeong, Yong | - |
dc.contributor.localauthor | Jon, Sangyong | - |
dc.contributor.localauthor | Kim, Pilhan | - |
dc.contributor.localauthor | Jeong, Ki-Hun | - |
dc.contributor.nonIdAuthor | Kim, Daniel Youngsuk | - |
dc.contributor.nonIdAuthor | Lee, Soyoung | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | OPTICAL COHERENCE TOMOGRAPHY | - |
dc.subject.keywordPlus | FIBER | - |
dc.subject.keywordPlus | MICROSCOPE | - |
dc.subject.keywordPlus | ENDOSCOPY | - |
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