DC Field | Value | Language |
---|---|---|
dc.contributor.author | Murphy, Coleen T. | ko |
dc.contributor.author | Lee, Seung-Jae | ko |
dc.contributor.author | Kenyon, Cynthia | ko |
dc.date.accessioned | 2019-03-19T01:37:19Z | - |
dc.date.available | 2019-03-19T01:37:19Z | - |
dc.date.created | 2019-03-06 | - |
dc.date.issued | 2007-11 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.104, no.48, pp.19046 - 19050 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/251729 | - |
dc.description.abstract | How are the rates of aging of different tissues coordinated? In Caenorhabditis elegans, decreasing insulin/IGF-1 signaling extends lifespan by activating the transcription factor DAF-16/FOXO. If DAF-16 levels are experimentally increased in one tissue, such as the intestine, DAF-16 activity in other tissues rises. Here we test the hypothesis that this '' FOXO-to-FOXO '' signaling occurs via feedback regulation of ins-7 insulin gene expression. We find that DAF-16 regulates ins-7 expression in the intestine, and that preventing this regulation blocks FOXO-to-FOXO signaling from the intestine to other tissues. Our findings show that feedback regulation of insulin gene expression coordinates DAF-16 activity among the tissues, and they establish the intestine, which is the animal's entire endoderm, as an important insulin-signaling center. | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans | - |
dc.type | Article | - |
dc.identifier.wosid | 000251498700033 | - |
dc.identifier.scopusid | 2-s2.0-37649022616 | - |
dc.type.rims | ART | - |
dc.citation.volume | 104 | - |
dc.citation.issue | 48 | - |
dc.citation.beginningpage | 19046 | - |
dc.citation.endingpage | 19050 | - |
dc.citation.publicationname | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.identifier.doi | 10.1073/pnas.0709613104 | - |
dc.contributor.localauthor | Lee, Seung-Jae | - |
dc.contributor.nonIdAuthor | Murphy, Coleen T. | - |
dc.contributor.nonIdAuthor | Kenyon, Cynthia | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | aging | - |
dc.subject.keywordAuthor | DAF-2 | - |
dc.subject.keywordAuthor | DAF-16 | - |
dc.subject.keywordAuthor | FOXO | - |
dc.subject.keywordPlus | C-ELEGANS | - |
dc.subject.keywordPlus | LIFE-SPAN | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | PROTEIN DAF-16 | - |
dc.subject.keywordPlus | LONGEVITY | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | DIAPAUSE | - |
dc.subject.keywordPlus | MEMBER | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
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