DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Ara B. | ko |
dc.contributor.author | Lee, Seung-Jae | ko |
dc.date.accessioned | 2019-03-19T01:37:03Z | - |
dc.date.available | 2019-03-19T01:37:03Z | - |
dc.date.created | 2019-03-06 | - |
dc.date.issued | 2011-03 | - |
dc.identifier.citation | AGING-US, v.3, no.3, pp.304 - 310 | - |
dc.identifier.issn | 1945-4589 | - |
dc.identifier.uri | http://hdl.handle.net/10203/251720 | - |
dc.description.abstract | A mild reduction in mitochondrial respiration extends the life span of many species, including C. elegans. We recently showed that hypoxia-inducible factor 1 (HIF-1) is required for the acquisition of a long life span by mutants with reduced respiration in C. elegans. We suggested that increased levels of reactive oxygen species (ROS) produced in the respiration mutants increase HIF-1 activity and lead to this longevity. In this research perspective, we discuss our findings and recent advances regarding the roles of ROS and HIF-1 in aging, focusing on the longevity caused by reduced respiration. | - |
dc.language | English | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.title | Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection | - |
dc.type | Article | - |
dc.identifier.wosid | 000289311900013 | - |
dc.identifier.scopusid | 2-s2.0-80051647245 | - |
dc.type.rims | ART | - |
dc.citation.volume | 3 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 304 | - |
dc.citation.endingpage | 310 | - |
dc.citation.publicationname | AGING-US | - |
dc.identifier.doi | 10.18632/aging.100292 | - |
dc.contributor.localauthor | Lee, Seung-Jae | - |
dc.contributor.nonIdAuthor | Hwang, Ara B. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | NEMATODE CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | C-ELEGANS | - |
dc.subject.keywordPlus | ELECTRON-TRANSPORT | - |
dc.subject.keywordPlus | ENERGY-METABOLISM | - |
dc.subject.keywordPlus | COMPLEX-III | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | HYPOXIA | - |
dc.subject.keywordPlus | MUTANTS | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
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