Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1 alpha

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Robust mitochondrial respiration provides energy to support physical performance and physiological well-being, whereas mitochondrial malfunction is associated with various pathologies and reduced longevity. In the current study, we tested whether myricetin, a natural flavonol with diverse biological activities, may impact mitochondrial function and longevity. The mice were orally administered myricetin (50 mg/kg/day) for 3 weeks. Myricetin significantly potentiated aerobic capacity in mice, as evidenced by their increased running time and distance. The elevated mitochondrial function was associated with induction of genes for oxidative phosphorylation and mitochondrial biogenesis in metabolically active tissues. Importantly, myricetin treatment led to decreased PGC-1 alpha acetylation through SIRT1 activation. Furthermore, myricetin significantly improved the healthspan and lifespan of wild-type, but not Sir-2.1-deficient, C. elegans. These results demonstrate that myricetin enhances mitochondrial activity, possibly by activating PGC-1 alpha and SIRT1, to improve physical endurance, strongly suggesting myricetin as a mitochondria-activating agent.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2017-07
Language
English
Article Type
Article
Citation

SCIENTIFIC REPORTS, v.7

ISSN
2045-2322
DOI
10.1038/s41598-017-05303-2
URI
http://hdl.handle.net/10203/251670
Appears in Collection
BS-Journal Papers(저널논문)
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