The role of RNA helicases in aging and lifespan regulation

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RNA helicases are members of a large family of enzymes that function in unwinding RNA duplexes and modulating interactions between RNAs and proteins. RNA helicases participate in numerous cellular processes, including transcription, translation, mRNA export, nonsense-mediated mRNA decay, and telomere maintenance. In this review, we discuss the recent discoveries on several RNA helicases that play key roles in aging and lifespan regulation. We first describe the roles of several mammalian RNA helicases implicated in cellular senescence. In addition, we discuss our previous reports showing that three RNA helicases, HEL-1/DDX39, SACY-1/DDX41 and SMG-2/UPF1, promote longevity in Caenorhabditis elegans through distinct mechanisms. These findings reveal the critical functions of many RNA helicases in regulating aging and may lead to insights into the importance of RNA homeostasis in aging and longevity.
Publisher
KeAi Publishing Communications
Issue Date
2017-10
Language
English
Citation

Translational Medicine of Aging, v.1, pp.24 - 31

ISSN
2468-5011
DOI
10.1016/j.tma.2017.08.001
URI
http://hdl.handle.net/10203/251667
Appears in Collection
BS-Journal Papers(저널논문)
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