RNAi targeting Caenorhabditis elegans α-arrestins has small or no effects on lifespan

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Background: α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization. Methods: Here, we sought to examine the roles of α-arrestins in the longevity of Caenorhabditis elegans through an RNA interference screen. Results: We found that knocking down each of 24 out of total 29 C. elegans α-arrestins had small or no effects on lifespan. Thus, individual C. elegans α-arrestins may have minor effects on longevity. Conclusions: This study will provide useful information for future research on the functional role of α-arrestins in aging and longevity.
Publisher
F1000Research 2017
Issue Date
2017-12
Language
English
Article Type
Article
Citation

F1000Research, v.6

ISSN
2046-1402
DOI
10.12688/f1000research.12337.4
URI
http://hdl.handle.net/10203/251666
Appears in Collection
BS-Journal Papers(저널논문)
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