DC Field | Value | Language |
---|---|---|
dc.contributor.author | Son, Heehwa G. | ko |
dc.contributor.author | Seo, Keunhee | ko |
dc.contributor.author | Seo, Mihwa | ko |
dc.contributor.author | Park, Sangsoon | ko |
dc.contributor.author | Ham, Seokjin | ko |
dc.contributor.author | An, Seon Woo A. | ko |
dc.contributor.author | Choi, Eun-Seok | ko |
dc.contributor.author | Lee, Yujin | ko |
dc.contributor.author | Baek, Haeshim | ko |
dc.contributor.author | Kim, Eunju | ko |
dc.contributor.author | Ryu, Youngjae | ko |
dc.contributor.author | Ha, Chang Man | ko |
dc.contributor.author | Hsu, Ao-Lin | ko |
dc.contributor.author | Roh, Tae-Young | ko |
dc.contributor.author | Jang, Sung Key | ko |
dc.contributor.author | Lee, Seung-Jae V. | ko |
dc.date.accessioned | 2019-03-19T01:27:29Z | - |
dc.date.available | 2019-03-19T01:27:29Z | - |
dc.date.created | 2019-03-06 | - |
dc.date.created | 2019-03-06 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.citation | GENES & DEVELOPMENT, v.32, no.23-24, pp.1562 - 1575 | - |
dc.identifier.issn | 0890-9369 | - |
dc.identifier.uri | http://hdl.handle.net/10203/251657 | - |
dc.description.abstract | Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In Caenorhabditis elegans, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and FOXO cooperate to confer IIS-mediated longevity. Here, we show that prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS. We found that PFD-6 was specifically required for reduced IIS-mediated longevity by acting in the intestine and hypodermis. We showed that HSF-1 increased the levels of PFD-6 proteins, which in turn directly bound FOXO and enhanced its transcriptional activity. Our work suggests that the prefoldin-like chaperone complex mediates longevity response from HSF-1 to FOXO to increase the life span in animals with reduced IIS. | - |
dc.language | English | - |
dc.publisher | COLD SPRING HARBOR LAB PRESS | - |
dc.title | Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C-elegans | - |
dc.type | Article | - |
dc.identifier.wosid | 000451905400010 | - |
dc.identifier.scopusid | 2-s2.0-85059890508 | - |
dc.type.rims | ART | - |
dc.citation.volume | 32 | - |
dc.citation.issue | 23-24 | - |
dc.citation.beginningpage | 1562 | - |
dc.citation.endingpage | 1575 | - |
dc.citation.publicationname | GENES & DEVELOPMENT | - |
dc.identifier.doi | 10.1101/gad.317362.118 | - |
dc.contributor.localauthor | Lee, Seung-Jae V. | - |
dc.contributor.nonIdAuthor | Son, Heehwa G. | - |
dc.contributor.nonIdAuthor | Seo, Keunhee | - |
dc.contributor.nonIdAuthor | Seo, Mihwa | - |
dc.contributor.nonIdAuthor | Park, Sangsoon | - |
dc.contributor.nonIdAuthor | Ham, Seokjin | - |
dc.contributor.nonIdAuthor | An, Seon Woo A. | - |
dc.contributor.nonIdAuthor | Choi, Eun-Seok | - |
dc.contributor.nonIdAuthor | Lee, Yujin | - |
dc.contributor.nonIdAuthor | Baek, Haeshim | - |
dc.contributor.nonIdAuthor | Kim, Eunju | - |
dc.contributor.nonIdAuthor | Ryu, Youngjae | - |
dc.contributor.nonIdAuthor | Ha, Chang Man | - |
dc.contributor.nonIdAuthor | Hsu, Ao-Lin | - |
dc.contributor.nonIdAuthor | Roh, Tae-Young | - |
dc.contributor.nonIdAuthor | Jang, Sung Key | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | aging | - |
dc.subject.keywordAuthor | C. elegans | - |
dc.subject.keywordAuthor | DAF-16/FOXO | - |
dc.subject.keywordAuthor | HSF-1/HSF1 | - |
dc.subject.keywordAuthor | PFD-6/PFDN6 | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | LIFE-SPAN | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | INTEGRATIVE ANALYSIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DAF-16 | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CHAPERONE | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | HSP90 | - |
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