Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's beta-amyloid aggregation
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ahn, Minkoo | ko |
| dc.contributor.author | Lee, Byung Il | ko |
| dc.contributor.author | Chia, Sean | ko |
| dc.contributor.author | Habchi, Johnny | ko |
| dc.contributor.author | Kumita, Janet R. | ko |
| dc.contributor.author | Vendruscolo, Michele | ko |
| dc.contributor.author | Dobson, Christopher M. | ko |
| dc.contributor.author | Park, Chan Beum | ko |
| dc.date.accessioned | 2019-03-19T01:27:03Z | - |
| dc.date.available | 2019-03-19T01:27:03Z | - |
| dc.date.created | 2019-03-04 | - |
| dc.date.issued | 2019-01 | - |
| dc.identifier.citation | CHEMICAL COMMUNICATIONS, v.55, no.8, pp.1152 - 1155 | - |
| dc.identifier.issn | 1359-7345 | - |
| dc.identifier.uri | http://hdl.handle.net/10203/251648 | - |
| dc.description.abstract | The self-assembly of the beta-amyloid peptide (A) into amyloid aggregates is a central phenomenon associated with Alzheimer's disease. Here, we report chemical modifications of key amino acid residues of A(42) (Y10, H13, H14, and M35) by photoexcited thioflavin-T (ThT), a fluorescent probe of amyloid structure. The quantitative chemical kinetics analysis shows that the oxidized monomer species does not self-assemble, nor perturb the aggregation kinetics of non-oxidized A beta(42). | - |
| dc.language | English | - |
| dc.publisher | ROYAL SOC CHEMISTRY | - |
| dc.title | Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's beta-amyloid aggregation | - |
| dc.type | Article | - |
| dc.identifier.wosid | 000458544800031 | - |
| dc.identifier.scopusid | 2-s2.0-85060212936 | - |
| dc.type.rims | ART | - |
| dc.citation.volume | 55 | - |
| dc.citation.issue | 8 | - |
| dc.citation.beginningpage | 1152 | - |
| dc.citation.endingpage | 1155 | - |
| dc.citation.publicationname | CHEMICAL COMMUNICATIONS | - |
| dc.identifier.doi | 10.1039/c8cc09288e | - |
| dc.contributor.localauthor | Park, Chan Beum | - |
| dc.contributor.nonIdAuthor | Ahn, Minkoo | - |
| dc.contributor.nonIdAuthor | Chia, Sean | - |
| dc.contributor.nonIdAuthor | Habchi, Johnny | - |
| dc.contributor.nonIdAuthor | Kumita, Janet R. | - |
| dc.contributor.nonIdAuthor | Vendruscolo, Michele | - |
| dc.contributor.nonIdAuthor | Dobson, Christopher M. | - |
| dc.description.isOpenAccess | N | - |
| dc.type.journalArticle | Article | - |
| dc.subject.keywordPlus | ATOMIC-RESOLUTION STRUCTURE | - |
| dc.subject.keywordPlus | BINDING MODES | - |
| dc.subject.keywordPlus | THIOFLAVIN-T | - |
| dc.subject.keywordPlus | PEPTIDE | - |
| dc.subject.keywordPlus | KINETICS | - |
| dc.subject.keywordPlus | DISEASE | - |
| dc.subject.keywordPlus | OCCURS | - |
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