Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's beta-amyloid aggregation

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dc.contributor.authorAhn, Minkooko
dc.contributor.authorLee, Byung Ilko
dc.contributor.authorChia, Seanko
dc.contributor.authorHabchi, Johnnyko
dc.contributor.authorKumita, Janet R.ko
dc.contributor.authorVendruscolo, Micheleko
dc.contributor.authorDobson, Christopher M.ko
dc.contributor.authorPark, Chan Beumko
dc.date.accessioned2019-03-19T01:27:03Z-
dc.date.available2019-03-19T01:27:03Z-
dc.date.created2019-03-04-
dc.date.issued2019-01-
dc.identifier.citationCHEMICAL COMMUNICATIONS, v.55, no.8, pp.1152 - 1155-
dc.identifier.issn1359-7345-
dc.identifier.urihttp://hdl.handle.net/10203/251648-
dc.description.abstractThe self-assembly of the beta-amyloid peptide (A) into amyloid aggregates is a central phenomenon associated with Alzheimer's disease. Here, we report chemical modifications of key amino acid residues of A(42) (Y10, H13, H14, and M35) by photoexcited thioflavin-T (ThT), a fluorescent probe of amyloid structure. The quantitative chemical kinetics analysis shows that the oxidized monomer species does not self-assemble, nor perturb the aggregation kinetics of non-oxidized A beta(42).-
dc.languageEnglish-
dc.publisherROYAL SOC CHEMISTRY-
dc.titleChemical and mechanistic analysis of photodynamic inhibition of Alzheimer's beta-amyloid aggregation-
dc.typeArticle-
dc.identifier.wosid000458544800031-
dc.identifier.scopusid2-s2.0-85060212936-
dc.type.rimsART-
dc.citation.volume55-
dc.citation.issue8-
dc.citation.beginningpage1152-
dc.citation.endingpage1155-
dc.citation.publicationnameCHEMICAL COMMUNICATIONS-
dc.identifier.doi10.1039/c8cc09288e-
dc.contributor.localauthorPark, Chan Beum-
dc.contributor.nonIdAuthorAhn, Minkoo-
dc.contributor.nonIdAuthorChia, Sean-
dc.contributor.nonIdAuthorHabchi, Johnny-
dc.contributor.nonIdAuthorKumita, Janet R.-
dc.contributor.nonIdAuthorVendruscolo, Michele-
dc.contributor.nonIdAuthorDobson, Christopher M.-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusATOMIC-RESOLUTION STRUCTURE-
dc.subject.keywordPlusBINDING MODES-
dc.subject.keywordPlusTHIOFLAVIN-T-
dc.subject.keywordPlusPEPTIDE-
dc.subject.keywordPlusKINETICS-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusOCCURS-
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