DC Field | Value | Language |
---|---|---|
dc.contributor.author | Baek, Jinhee | ko |
dc.contributor.author | Lee, Sukchan | ko |
dc.contributor.author | Cho, Taesup | ko |
dc.contributor.author | Kim, Seong-Wook | ko |
dc.contributor.author | Kim, Minsoo | ko |
dc.contributor.author | Yoon, Yongwoo | ko |
dc.contributor.author | Kim, Ko Keun | ko |
dc.contributor.author | Byun, Junweon | ko |
dc.contributor.author | Kim, Sang Jeong | ko |
dc.contributor.author | Jeong, Jaeseung | ko |
dc.contributor.author | Shin, Hee-Sup | ko |
dc.date.accessioned | 2019-03-19T01:26:01Z | - |
dc.date.available | 2019-03-19T01:26:01Z | - |
dc.date.created | 2019-03-04 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.citation | NATURE, v.566, no.7744, pp.339 - + | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | http://hdl.handle.net/10203/251636 | - |
dc.description.abstract | A psychotherapeutic regimen that uses alternating bilateral sensory stimulation (ABS) has been used to treat post-traumatic stress disorder. However, the neural basis that underlies the long-lasting effect of this treatment-described as eye movement desensitization and reprocessing-has not been identified. Here we describe a neuronal pathway driven by the superior colliculus (SC) that mediates persistent attenuation of fear. We successfully induced a lasting reduction in fear in mice by pairing visual ABS with conditioned stimuli during fear extinction. Among the types of visual stimulation tested, ABS provided the strongest fear-reducing effect and yielded sustained increases in the activities of the SC and mediodorsal thalamus (MD). Optogenetic manipulation revealed that the SC-MD circuit was necessary and sufficient to prevent the return of fear. ABS suppressed the activity of fear-encoding cells and stabilized inhibitory neurotransmission in the basolateral amygdala through a feedforward inhibitory circuit from the MD. Together, these results reveal the neural circuit that underlies an effective strategy for sustainably attenuating traumatic memories. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Neural circuits underlying a psychotherapeutic regimen for fear disorders | - |
dc.type | Article | - |
dc.identifier.wosid | 000459119200038 | - |
dc.identifier.scopusid | 2-s2.0-85061770073 | - |
dc.type.rims | ART | - |
dc.citation.volume | 566 | - |
dc.citation.issue | 7744 | - |
dc.citation.beginningpage | 339 | - |
dc.citation.endingpage | + | - |
dc.citation.publicationname | NATURE | - |
dc.identifier.doi | 10.1038/s41586-019-0931-y | - |
dc.contributor.localauthor | Jeong, Jaeseung | - |
dc.contributor.nonIdAuthor | Lee, Sukchan | - |
dc.contributor.nonIdAuthor | Cho, Taesup | - |
dc.contributor.nonIdAuthor | Kim, Seong-Wook | - |
dc.contributor.nonIdAuthor | Kim, Minsoo | - |
dc.contributor.nonIdAuthor | Yoon, Yongwoo | - |
dc.contributor.nonIdAuthor | Kim, Ko Keun | - |
dc.contributor.nonIdAuthor | Byun, Junweon | - |
dc.contributor.nonIdAuthor | Kim, Sang Jeong | - |
dc.contributor.nonIdAuthor | Shin, Hee-Sup | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | COGNITIVE-BEHAVIORAL THERAPY | - |
dc.subject.keywordPlus | POSTTRAUMATIC-STRESS-DISORDER | - |
dc.subject.keywordPlus | EYE-MOVEMENT DESENSITIZATION | - |
dc.subject.keywordPlus | SUPERIOR COLLICULUS | - |
dc.subject.keywordPlus | MEDIODORSAL THALAMUS | - |
dc.subject.keywordPlus | CORTEX | - |
dc.subject.keywordPlus | EXTINCTION | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | ERASURE | - |
dc.subject.keywordPlus | STIMULATION | - |
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