Self-aggregates of oligoarginine-conjugated poly(amino acid) derivatives as a carrier for intracellular drug delivery

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Nx-2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl (Nx-Pbf)-protected oligoarginine was directly conjugated to poly(amino acid) derivatives modified with a long alkyl chain. The final concentration of conjugated peptides was easily controlled by the feed ratio of oligoarginine to polymer backbone and a final soluble polymeric system was obtained by the deprotection of Nx-Pbf groups. The polymeric conjugates formed stable self-aggregates of size range of 8–40 nm in aqueous solution and effectively internalized into HeLa cells by adsorptive endocytosis.
Publisher
Springer Verlag
Issue Date
2005
Keywords

intracellular delivery; oligoarginine; poly(amino acid)s; self-aggregates

Citation

Biotechnology Letters, Vol.27, pp.977-982

DOI
10.1007/s10529-005-7838-4
URI
http://hdl.handle.net/10203/25127
Appears in Collection
CBE-Journal Papers(저널논문)

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