BC200 RNA: An Emerging Therapeutic Target and Diagnostic Marker for Human Cancer

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One of the most interesting findings from genome-wide expression analysis is that a considerable amount of noncoding RNA (ncRNA) is present in the cell. Recent studies have identified diverse biological functions of ncRNAs, which are expressed in a much wider array of forms than proteins. Certain ncRNAs associated with diseases, in particular, have attracted research attention as novel therapeutic targets and diagnostic markers. BC200 RNA, a 200-nucleotide ncRNA originally identified as a neuron-specific transcript, is abnormally overexpressed in several types of cancer tissue. A number of recent studies have suggested mechanisms by which abnormal expression of BC200 RNA contributes to the development of cancer. In this article, we first provide a brief review of a recent progress in identifying functions of BC200 RNA in cancer cells, and then offer examples of other ncRNAs as new therapeutic targets and diagnostic markers for human cancer. Finally, we discuss future directions of studies on BC200 RNA for new cancer treatments.
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Issue Date
2018-12
Language
English
Article Type
Review
Citation

MOLECULES AND CELLS, v.41, no.12, pp.993 - 999

ISSN
1016-8478
DOI
10.14348/molcells.2018.0425
URI
http://hdl.handle.net/10203/250138
Appears in Collection
CH-Journal Papers(저널논문)
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