동맥경화의 미세환경에서 대식세포의 사멸에 의한 혈관세포의 기능적 변화에 대한 가시화Visualization on the Functional Changes of Endothelial Cells Due to Apoptotic Macrophage in Atherosclerosis Microenvironment

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The apoptosis of macrophages occurs throughout all stages of atherosclerosis. It is known to constitute atheromatous plaque, increase plaque instability, and thus contribute to the development of atherosclerosis. However, there still remains much to be elucidated on how the apoptotic macrophages affect the endothelial cells and also how they contribute to the development of atherosclerosis. Here we present a microfluidic system, which enables co-culture of apoptotic macrophages and endothelial cells in fibrin gel that mimics in vivo extracellular matrix. With the system, we can investigate the effect of macrophage apoptosis on vascular endothelial cells by quantitatively analyzing the level of reactive oxygen species of HUVECs, integrity of VE-cadherin and cell proliferation. We expect that this system could be utilized further for understanding different mechanisms of apoptotic macrophage on the development of atherosclerosis.
Publisher
한국가시화정보학회
Issue Date
2017-12
Language
Korean
Citation

한국가시화정보학회지, v.15, no.3, pp.41 - 46

ISSN
1598-8430
DOI
10.5407/JKSV.2017.15.3.041
URI
http://hdl.handle.net/10203/250030
Appears in Collection
ME-Journal Papers(저널논문)
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