DC Field | Value | Language |
---|---|---|
dc.contributor.author | Xu, Jun | ko |
dc.contributor.author | Lee, Steve Seung-Young | ko |
dc.contributor.author | Seo, Howon | ko |
dc.contributor.author | Pang, Liang | ko |
dc.contributor.author | Jun, Yearin | ko |
dc.contributor.author | Zhang, Ruo-Yu | ko |
dc.contributor.author | Zhang, Zhong-Yin | ko |
dc.contributor.author | Kim, Pilhan | ko |
dc.contributor.author | Lee, Wooin | ko |
dc.contributor.author | Kron, Stephen J. | ko |
dc.contributor.author | Yeo, Yoon | ko |
dc.date.accessioned | 2019-01-23T05:50:56Z | - |
dc.date.available | 2019-01-23T05:50:56Z | - |
dc.date.created | 2019-01-07 | - |
dc.date.created | 2019-01-07 | - |
dc.date.created | 2019-01-07 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.citation | SMALL, v.14, no.50 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.uri | http://hdl.handle.net/10203/249799 | - |
dc.description.abstract | Current nanoparticle (NP) drug carriers mostly depend on the enhanced permeability and retention (EPR) effect for selective drug delivery to solid tumors. However, in the absence of a persistent EPR effect, the peritumoral endothelium can function as an access barrier to tumors and negatively affect the effectiveness of NPs. In recognition of the peritumoral endothelium as a potential barrier in drug delivery to tumors, poly(lactic-co-glycolic acid) (PLGA) NPs are modified with a quinic acid (QA) derivative, synthetic mimic of selectin ligands. QA-decorated NPs (QA-NP) interact with human umbilical vein endothelial cells expressing E-/P-selectins and induce transient increase in endothelial permeability to translocate across the layer. QA-NP reach selectin-upregulated tumors, achieving greater tumor accumulation and paclitaxel (PTX) delivery than polyethylene glycol-decorated NPs (PEG-NP). PTX-loaded QA-NP show greater anticancer efficacy than Taxol or PTX-loaded PEG-NP at the equivalent PTX dose in different animal models and dosing regimens. Repeated dosing of PTX-loaded QA-NP for two weeks results in complete tumor remission in 40-60% of MDA-MB-231 tumor-bearing mice, while those receiving control treatments succumb to death. QA-NP can exploit the interaction with selectin-expressing peritumoral endothelium and deliver anticancer drugs to tumors to a greater extent than the level currently possible with the EPR effect. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins | - |
dc.type | Article | - |
dc.identifier.wosid | 000453627100020 | - |
dc.identifier.scopusid | 2-s2.0-85056307066 | - |
dc.type.rims | ART | - |
dc.citation.volume | 14 | - |
dc.citation.issue | 50 | - |
dc.citation.publicationname | SMALL | - |
dc.identifier.doi | 10.1002/smll.201803601 | - |
dc.contributor.localauthor | Kim, Pilhan | - |
dc.contributor.nonIdAuthor | Xu, Jun | - |
dc.contributor.nonIdAuthor | Lee, Steve Seung-Young | - |
dc.contributor.nonIdAuthor | Pang, Liang | - |
dc.contributor.nonIdAuthor | Jun, Yearin | - |
dc.contributor.nonIdAuthor | Zhang, Ruo-Yu | - |
dc.contributor.nonIdAuthor | Zhang, Zhong-Yin | - |
dc.contributor.nonIdAuthor | Lee, Wooin | - |
dc.contributor.nonIdAuthor | Kron, Stephen J. | - |
dc.contributor.nonIdAuthor | Yeo, Yoon | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | polymeric nanoparticles | - |
dc.subject.keywordAuthor | quinic acid | - |
dc.subject.keywordAuthor | selectin | - |
dc.subject.keywordAuthor | tumor microenvironment | - |
dc.subject.keywordPlus | ACCELERATED BLOOD CLEARANCE | - |
dc.subject.keywordPlus | CELL-ADHESION MOLECULES | - |
dc.subject.keywordPlus | P-SELECTIN | - |
dc.subject.keywordPlus | PEGYLATED LIPOSOMES | - |
dc.subject.keywordPlus | SIALYL LEWIS(X) | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | TRANSENDOTHELIAL MIGRATION | - |
dc.subject.keywordPlus | METASTATIC TUMORS | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
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