Reconstructing Pseudo-Continuous Arterial Spin Labeling Perfusion Signals through Modulation of Labeling RF Power and Fourier Analysis

Abstract

The conventional pCASL is vulnerable to data corruption and has high specific absorption rate. In this study, we propose a new pCASL approach using modulation of labeling RF pulse power and Fourier analysis. The proposed approach enabled us to acquire perfusion images comparable to those of the conventional pCASL. Under data corruption, the proposed approach maintained the perfusion signals well with no observable effect, while the conventional method showed almost no perfusion signal. The proposed approach has relatively low average SAR and instantaneous SAR, potentially advantageous at high fields. These advantages of the proposed method warrant further investigation.