DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gang, Dong Hyeok | ko |
dc.contributor.author | Kim, Do Wook | ko |
dc.contributor.author | Park, Hee-Sung | ko |
dc.date.accessioned | 2018-12-20T08:03:36Z | - |
dc.date.available | 2018-12-20T08:03:36Z | - |
dc.date.created | 2018-12-14 | - |
dc.date.created | 2018-12-14 | - |
dc.date.issued | 2018-11 | - |
dc.identifier.citation | GENES, v.9, no.11 | - |
dc.identifier.issn | 2073-4425 | - |
dc.identifier.uri | http://hdl.handle.net/10203/248723 | - |
dc.description.abstract | To date, small molecules and macromolecules, including antibodies, have been the most pursued substances in drug screening and development efforts. Despite numerous favorable features as a drug, these molecules still have limitations and are not complementary in many regards. Recently, peptide-based chemical structures that lie between these two categories in terms of both structural and functional properties have gained increasing attention as potential alternatives. In particular, peptides in a circular form provide a promising scaffold for the development of a novel drug class owing to their adjustable and expandable ability to bind a wide range of target molecules. In this review, we discuss recent progress in methodologies for peptide cyclization and screening and use of bioactive cyclic peptides in various applications. © 2018 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.title | Cyclic peptides: Promising scaffolds for biopharmaceuticals | - |
dc.type | Article | - |
dc.identifier.wosid | 000451636700042 | - |
dc.identifier.scopusid | 2-s2.0-85057119987 | - |
dc.type.rims | ART | - |
dc.citation.volume | 9 | - |
dc.citation.issue | 11 | - |
dc.citation.publicationname | GENES | - |
dc.identifier.doi | 10.3390/genes9110557 | - |
dc.contributor.localauthor | Park, Hee-Sung | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordAuthor | cyclic peptides | - |
dc.subject.keywordAuthor | biopharmaceuticals | - |
dc.subject.keywordAuthor | mRNA display | - |
dc.subject.keywordAuthor | yeast two hybrid | - |
dc.subject.keywordPlus | MESSENGER-RNA DISPLAY | - |
dc.subject.keywordPlus | IMPROVING TUMOR UPTAKE | - |
dc.subject.keywordPlus | IN-VITRO SELECTION | - |
dc.subject.keywordPlus | PROTEIN INTERACTIONS | - |
dc.subject.keywordPlus | THIOESTERASE DOMAIN | - |
dc.subject.keywordPlus | RIBOSOMAL SYNTHESIS | - |
dc.subject.keywordPlus | RATIONAL DESIGN | - |
dc.subject.keywordPlus | PHAGE DISPLAY | - |
dc.subject.keywordPlus | SPLIT INTEIN | - |
dc.subject.keywordPlus | RGD PEPTIDE | - |
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