Cyclic peptides: Promising scaffolds for biopharmaceuticals

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To date, small molecules and macromolecules, including antibodies, have been the most pursued substances in drug screening and development efforts. Despite numerous favorable features as a drug, these molecules still have limitations and are not complementary in many regards. Recently, peptide-based chemical structures that lie between these two categories in terms of both structural and functional properties have gained increasing attention as potential alternatives. In particular, peptides in a circular form provide a promising scaffold for the development of a novel drug class owing to their adjustable and expandable ability to bind a wide range of target molecules. In this review, we discuss recent progress in methodologies for peptide cyclization and screening and use of bioactive cyclic peptides in various applications. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Publisher
MDPI AG
Issue Date
2018-11
Language
English
Article Type
Review
Citation

GENES, v.9, no.11

ISSN
2073-4425
DOI
10.3390/genes9110557
URI
http://hdl.handle.net/10203/248723
Appears in Collection
CH-Journal Papers(저널논문)
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