DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koo, Jahyun | ko |
dc.contributor.author | MacEwan, Matthew R. | ko |
dc.contributor.author | Kang, Seung-Kyun | ko |
dc.contributor.author | Won, Sang Min | ko |
dc.contributor.author | Stephen, Manu | ko |
dc.contributor.author | Gamble, Paul | ko |
dc.contributor.author | Xie, Zhaoqian | ko |
dc.contributor.author | Yan, Ying | ko |
dc.contributor.author | Chen, Yu-Yu | ko |
dc.contributor.author | Shin, Jiho | ko |
dc.contributor.author | Birenbaum, Nathan | ko |
dc.contributor.author | Chung, Sangjin | ko |
dc.contributor.author | Kim, Sung Bong | ko |
dc.contributor.author | Khalifeh, Jawad | ko |
dc.contributor.author | Harburg, Daniel V. | ko |
dc.contributor.author | Bean, Kelsey | ko |
dc.contributor.author | Paskett, Michael | ko |
dc.contributor.author | Kim, Jeonghyun | ko |
dc.contributor.author | Zohny, Zohny S. | ko |
dc.contributor.author | Lee, Seung Min | ko |
dc.contributor.author | Zhang, Ruoyao | ko |
dc.contributor.author | Luo, Kaijing | ko |
dc.contributor.author | Ji, Bowen | ko |
dc.contributor.author | Banks, Anthony | ko |
dc.contributor.author | Lee, Hyuck-Mo | ko |
dc.contributor.author | Huang, Younggang | ko |
dc.contributor.author | Ray, Wilson Z. | ko |
dc.contributor.author | Rogers, John A. | ko |
dc.date.accessioned | 2018-12-20T08:02:17Z | - |
dc.date.available | 2018-12-20T08:02:17Z | - |
dc.date.created | 2018-12-04 | - |
dc.date.created | 2018-12-04 | - |
dc.date.created | 2018-12-04 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.citation | NATURE MEDICINE, v.24, no.12, pp.1830 - + | - |
dc.identifier.issn | 1078-8956 | - |
dc.identifier.uri | http://hdl.handle.net/10203/248697 | - |
dc.description.abstract | Peripheral nerve injuries represent a significant problem in public health, constituting 2-5% of all trauma cases(1). For severe nerve injuries, even advanced forms of clinical intervention often lead to incomplete and unsatisfactory motor and/or sensory function(2). Numerous studies report the potential of pharmacological approaches (for example, growth factors, immunosuppressants) to accelerate and enhance nerve regeneration in rodent models(3-10). Unfortunately, few have had a positive impact in clinical practice. Direct intraoperative electrical stimulation of injured nerve tissue proximal to the site of repair has been demonstrated to enhance and accelerate functional recovery(11,12), suggesting a novel nonpharmacological, bioelectric form of therapy that could complement existing surgical approaches. A significant limitation of this technique is that existing protocols are constrained to intraoperative use and limited therapeutic benefits(13). Herein we introduce (i) a platform for wireless, programmable electrical peripheral nerve stimulation, built with a collection of circuit elements and substrates that are entirely bioresorbable and biocompatible, and (ii) the first reported demonstration of enhanced neuroregeneration and functional recovery in rodent models as a result of multiple episodes of electrical stimulation of injured nervous tissue. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy | - |
dc.type | Article | - |
dc.identifier.wosid | 000452392200011 | - |
dc.identifier.scopusid | 2-s2.0-85054577088 | - |
dc.type.rims | ART | - |
dc.citation.volume | 24 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 1830 | - |
dc.citation.endingpage | + | - |
dc.citation.publicationname | NATURE MEDICINE | - |
dc.identifier.doi | 10.1038/s41591-018-0196-2 | - |
dc.contributor.localauthor | Kang, Seung-Kyun | - |
dc.contributor.localauthor | Lee, Hyuck-Mo | - |
dc.contributor.nonIdAuthor | Koo, Jahyun | - |
dc.contributor.nonIdAuthor | MacEwan, Matthew R. | - |
dc.contributor.nonIdAuthor | Won, Sang Min | - |
dc.contributor.nonIdAuthor | Stephen, Manu | - |
dc.contributor.nonIdAuthor | Gamble, Paul | - |
dc.contributor.nonIdAuthor | Xie, Zhaoqian | - |
dc.contributor.nonIdAuthor | Yan, Ying | - |
dc.contributor.nonIdAuthor | Chen, Yu-Yu | - |
dc.contributor.nonIdAuthor | Shin, Jiho | - |
dc.contributor.nonIdAuthor | Birenbaum, Nathan | - |
dc.contributor.nonIdAuthor | Chung, Sangjin | - |
dc.contributor.nonIdAuthor | Kim, Sung Bong | - |
dc.contributor.nonIdAuthor | Khalifeh, Jawad | - |
dc.contributor.nonIdAuthor | Harburg, Daniel V. | - |
dc.contributor.nonIdAuthor | Bean, Kelsey | - |
dc.contributor.nonIdAuthor | Paskett, Michael | - |
dc.contributor.nonIdAuthor | Kim, Jeonghyun | - |
dc.contributor.nonIdAuthor | Zohny, Zohny S. | - |
dc.contributor.nonIdAuthor | Lee, Seung Min | - |
dc.contributor.nonIdAuthor | Zhang, Ruoyao | - |
dc.contributor.nonIdAuthor | Luo, Kaijing | - |
dc.contributor.nonIdAuthor | Ji, Bowen | - |
dc.contributor.nonIdAuthor | Banks, Anthony | - |
dc.contributor.nonIdAuthor | Huang, Younggang | - |
dc.contributor.nonIdAuthor | Ray, Wilson Z. | - |
dc.contributor.nonIdAuthor | Rogers, John A. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ACCELERATES AXON REGENERATION | - |
dc.subject.keywordPlus | PERIPHERAL-NERVE INJURIES | - |
dc.subject.keywordPlus | ELECTRICAL-STIMULATION | - |
dc.subject.keywordPlus | CONTROLLED-RELEASE | - |
dc.subject.keywordPlus | BIOCOMPATIBILITY | - |
dc.subject.keywordPlus | IMPLANTATION | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | FK506 | - |
dc.subject.keywordPlus | MUSCLE | - |
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