Expansion microscopy

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Super-resolution optical microscopy techniques have revolutionized how we see and understand biology. In recent past, a new super-resolution optical microscopy technique called expansion microscopy (ExM) was developed. Unlike other pre-existing super-resolution imaging techniques, this technique achieves super-resolution by physically expanding biological specimens via a swellable hydrogel. After the development of ExM, various techniques based on ExM but with improved performance in various aspects, have been developed. In this review, we introduce the basic principles of ExM and its variants. and compare the advantages and disadvantages of these techniques. In addition, we present the applications of ExM techniques in various fields.
Publisher
WILEY
Issue Date
2018-08
Language
English
Article Type
Review
Citation

JOURNAL OF MICROSCOPY, v.271, no.2, pp.123 - 128

ISSN
0022-2720
DOI
10.1111/jmi.12712
URI
http://hdl.handle.net/10203/247660
Appears in Collection
MS-Journal Papers(저널논문)
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