Genome-scale analysis of Acetobacterium bakii reveals the cold adaptation of psychrotolerant acetogens by post-transcriptional regulation

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dc.contributor.authorShin, Jongohko
dc.contributor.authorSong, Yosebko
dc.contributor.authorJin, Sangrakko
dc.contributor.authorLee, Jung-Kulko
dc.contributor.authorKim, Dong Ripko
dc.contributor.authorKim, Sun Changko
dc.contributor.authorCho, Suhyungko
dc.contributor.authorCho, Byung-Kwanko
dc.date.accessioned2018-12-20T05:09:01Z-
dc.date.available2018-12-20T05:09:01Z-
dc.date.created2018-12-03-
dc.date.created2018-12-03-
dc.date.issued2018-12-
dc.identifier.citationRNA, v.24, no.12, pp.1839 - 1855-
dc.identifier.issn1355-8382-
dc.identifier.urihttp://hdl.handle.net/10203/247600-
dc.description.abstractAcetogens synthesize acetyl-CoA via CO2 or CO fixation, producing organic compounds. Despite their ecological and industrial importance, their transcriptional and post-transcriptional regulation has not been systematically studied. With completion of the genome sequence of Acetobacterium bakii (4.28-Mb), we measured changes in the transcriptome of this psychrotolerant acetogen in response to temperature variations under autotrophic and heterotrophic growth conditions. Unexpectedly, acetogenesis genes were highly up-regulated at low temperatures under heterotrophic, as well as autotrophic, growth conditions. To mechanistically understand the transcriptional regulation of acetogenesis genes via changes in RNA secondary structures of 5'-untranslated regions (5'-UTR), the primary transcriptome was experimentally determined, and 1379 transcription start sites (TSS) and 1100 5'-UTR were found. Interestingly, acetogenesis genes contained longer 5'-UTR with lower RNA-folding free energy than other genes, revealing that the 5'-UTRs control the RNA abundance of the acetogenesis genes under low temperature conditions. Our findings suggest that post-transcriptional regulation via RNA conformational changes of 5'-UTRs is necessary for cold-adaptive acetogenesis.-
dc.languageEnglish-
dc.publisherCOLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT-
dc.titleGenome-scale analysis of Acetobacterium bakii reveals the cold adaptation of psychrotolerant acetogens by post-transcriptional regulation-
dc.typeArticle-
dc.identifier.wosid000450373800018-
dc.identifier.scopusid2-s2.0-85056570167-
dc.type.rimsART-
dc.citation.volume24-
dc.citation.issue12-
dc.citation.beginningpage1839-
dc.citation.endingpage1855-
dc.citation.publicationnameRNA-
dc.identifier.doi10.1261/rna.068239.118-
dc.contributor.localauthorKim, Sun Chang-
dc.contributor.localauthorCho, Byung-Kwan-
dc.contributor.nonIdAuthorLee, Jung-Kul-
dc.contributor.nonIdAuthorKim, Dong Rip-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorpost-transcriptional regulation-
dc.subject.keywordAuthorpsychrotolerant acetogen-
dc.subject.keywordAuthorAcetobacterium bakii-
dc.subject.keywordAuthorcold-adaptive acetogenesis-
dc.subject.keywordPlusMESSENGER-RNA STABILIZATION-
dc.subject.keywordPlusESCHERICHIA-COLI-
dc.subject.keywordPlusMETHANOGENIC ARCHAEA-
dc.subject.keywordPlusBACILLUS-SUBTILIS-
dc.subject.keywordPlusLOW-TEMPERATURE-
dc.subject.keywordPlusCOMMODITY CHEMICALS-
dc.subject.keywordPlusFAMILIES DATABASE-
dc.subject.keywordPlusSTART SITES-
dc.subject.keywordPlusBACTERIA-
dc.subject.keywordPlusMETABOLISM-
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