Epigenetics and epitranscriptomics in temporal patterning of cortical neural progenitor competence

Cited 49 time in webofscience Cited 0 time in scopus
  • Hit : 314
  • Download : 0
During embryonic brain development, neural progenitor/stem cells (NPCs) sequentially give rise to different subtypes of neurons and glia via a highly orchestrated process. To accomplish the ordered generation of distinct progenies, NPCs go through multistep transitions of their developmental competence. The molecular mechanisms driving precise temporal coordination of these transitions remains enigmatic. Epigenetic regulation, including changes in chromatin structures, DNA methylation, and histone modifications, has been extensively investigated in the context of cortical neurogenesis. Recent studies of chemical modifications on RNA, termed epitranscriptomics, have also revealed their critical roles in neural development. In this review, we discuss advances in understanding molecular regulation of the sequential lineage specification of NPCs in the embryonic mammalian brain with a focus on epigenetic and epitranscriptomic mechanisms. In particular, the discovery of lineage-specific gene transcripts undergoing rapid turnover in NPCs suggests that NPC developmental fate competence is determined much earlier, before the final cell division, and is more tightly controlled than previously appreciated. We discuss how multiple regulatory systems work in harmony to coordinate NPC behavior and summarize recent findings in the context of a model of epigenetic and transcriptional prepatterning to explain NPC developmental competence.
Publisher
ROCKEFELLER UNIV PRESS
Issue Date
2018-06
Language
English
Article Type
Review
Keywords

CHROMATIN REMODELING COMPLEX; STEM-CELL DIFFERENTIATION; MESSENGER-RNA METHYLATION; DEVELOPING CEREBRAL-CORTEX; ADULT MAMMALIAN BRAIN; NUCLEAR RECEPTOR TLX; SINGLE-CELL; DNA METHYLATION; HISTONE DEACETYLASES; GENE-EXPRESSION

Citation

JOURNAL OF CELL BIOLOGY, v.217, no.6, pp.1901 - 1914

ISSN
0021-9525
DOI
10.1083/jcb.201802117
URI
http://hdl.handle.net/10203/247153
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 49 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0