Mild Reduction of the Cancer Cell Surface as an Anti-invasion Treatment

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Cancer cell invasion is the main reason for high mortality in patients with malignant cancers. There has been little improvement in cancer prognosis because of a high rate of infiltration. Therefore, successful treatment requires inhibition of cancer cell invasion. Here, we suggest a new approach to inhibit cancer cell invasion through mild reduction of cell surface proteins to expose free thiols. Through mild reduction, the cancer cell surfaces present free active thiols at the membranes, enhancing cell adhesion to extracellular matrix and decreasing motility. Collectively, we suggest cell surface modification as a new therapeutic approach to treat invading malignant cancers.
Publisher
AMER CHEMICAL SOC
Issue Date
2018-10
Language
English
Article Type
Article
Citation

ACS APPLIED MATERIALS & INTERFACES, v.10, no.42, pp.35676 - 35680

ISSN
1944-8244
DOI
10.1021/acsami.8b12566
URI
http://hdl.handle.net/10203/246917
Appears in Collection
BiS-Journal Papers(저널논문)
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