Development of flexible, biocompatible, biodegradable, and small electronic components is of great interest for implantable medical devices. In this work, we present a highly dense silk-fibroin-based memristor array, fabricated using our newly developed fabrication technique based on UV photolithography. This is the first demonstration of silk-fibroin-based memristors implemented in a cross-bar architecture with a high cell density (single cell of 20 × 20 μm