Temporal Control of Mammalian Cortical Neurogenesis by m(6)A Methylation

Cited 382 time in webofscience Cited 0 time in scopus
  • Hit : 386
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorYoon, Ki-Junko
dc.contributor.authorRingeling, Francisca Rojasko
dc.contributor.authorVissers, Carolineko
dc.contributor.authorJacob, Fadiko
dc.contributor.authorPokrass, Michaelko
dc.contributor.authorJimenez-Cyrus, Dennisseko
dc.contributor.authorSu, Yijingko
dc.contributor.authorKim, Nam-Shikko
dc.contributor.authorZhu, Yunhuako
dc.contributor.authorZheng, Lilyko
dc.contributor.authorKim, Sunghanko
dc.contributor.authorWang, Xinyuanko
dc.contributor.authorDore, Louis C.ko
dc.contributor.authorJin, Pengko
dc.contributor.authorRegot, Sergiko
dc.contributor.authorZhuang, Xiaoxiko
dc.contributor.authorCanzar, Stefanko
dc.contributor.authorHe, Chuanko
dc.contributor.authorMing, Guo-liko
dc.contributor.authorSong, Hongjunko
dc.date.accessioned2018-10-19T00:42:35Z-
dc.date.available2018-10-19T00:42:35Z-
dc.date.created2018-10-05-
dc.date.created2018-10-05-
dc.date.created2018-10-05-
dc.date.issued2017-11-
dc.identifier.citationCELL, v.171, no.4, pp.877 - +-
dc.identifier.issn0092-8674-
dc.identifier.urihttp://hdl.handle.net/10203/246050-
dc.description.abstractN-6-methyladenosine (m(6)A), installed by the Mettl3/Mettl14 methyltransferase complex, is the most prevalent internal mRNA modification. Whether m(6)A regulates mammalian brain development is unknown. Here, we show that m(6)A depletion by Mettl14 knockout in embryonic mouse brains prolongs the cell cycle of radial glia cells and extends cortical neurogenesis into postnatal stages. m(6)A depletion by Mettl3 knockdown also leads to a prolonged cell cycle and maintenance of radial glia cells. m(6)A sequencing of embryonic mouse cortex reveals enrichment of mRNAs related to transcription factors, neurogenesis, the cell cycle, and neuronal differentiation, and m(6)A tagging promotes their decay. Further analysis uncovers previously unappreciated transcriptional prepatterning in cortical neural stem cells. m(6)A signaling also regulates human cortical neurogenesis in fore-brain organoids. Comparison of m(6)A-mRNA landscapes between mouse and human cortical neurogenesis reveals enrichment of human-specific m(6)A tagging of transcripts related to brain-disorder risk genes. Our study identifies an epitranscriptomic mechanism in heightened transcriptional coordination during mammalian cortical neurogenesis.-
dc.languageEnglish-
dc.publisherCELL PRESS-
dc.titleTemporal Control of Mammalian Cortical Neurogenesis by m(6)A Methylation-
dc.typeArticle-
dc.identifier.wosid000414250900016-
dc.identifier.scopusid2-s2.0-85030682434-
dc.type.rimsART-
dc.citation.volume171-
dc.citation.issue4-
dc.citation.beginningpage877-
dc.citation.endingpage+-
dc.citation.publicationnameCELL-
dc.identifier.doi10.1016/j.cell.2017.09.003-
dc.contributor.localauthorYoon, Ki-Jun-
dc.contributor.nonIdAuthorRingeling, Francisca Rojas-
dc.contributor.nonIdAuthorVissers, Caroline-
dc.contributor.nonIdAuthorJacob, Fadi-
dc.contributor.nonIdAuthorPokrass, Michael-
dc.contributor.nonIdAuthorJimenez-Cyrus, Dennisse-
dc.contributor.nonIdAuthorSu, Yijing-
dc.contributor.nonIdAuthorKim, Nam-Shik-
dc.contributor.nonIdAuthorZhu, Yunhua-
dc.contributor.nonIdAuthorZheng, Lily-
dc.contributor.nonIdAuthorKim, Sunghan-
dc.contributor.nonIdAuthorWang, Xinyuan-
dc.contributor.nonIdAuthorDore, Louis C.-
dc.contributor.nonIdAuthorJin, Peng-
dc.contributor.nonIdAuthorRegot, Sergi-
dc.contributor.nonIdAuthorZhuang, Xiaoxi-
dc.contributor.nonIdAuthorCanzar, Stefan-
dc.contributor.nonIdAuthorHe, Chuan-
dc.contributor.nonIdAuthorMing, Guo-li-
dc.contributor.nonIdAuthorSong, Hongjun-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusEMBRYONIC STEM-CELLS-
dc.subject.keywordPlusSEX DETERMINATION-
dc.subject.keywordPlusRNA METHYLATION-
dc.subject.keywordPlusHUMAN BRAIN-
dc.subject.keywordPlusNEOCORTEX-
dc.subject.keywordPlusSCHIZOPHRENIA-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusMODEL-
dc.subject.keywordPlusIDENTIFICATION-
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 382 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0