DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, Jae-Byum | ko |
dc.contributor.author | Chen, Fei | ko |
dc.contributor.author | Yoon, Young-Gyu | ko |
dc.contributor.author | Jung, Erica E. | ko |
dc.contributor.author | Babcock, Hazen | ko |
dc.contributor.author | Kang, Jeong Seuk | ko |
dc.contributor.author | Asano, Shoh | ko |
dc.contributor.author | Suk, Ho-Jun | ko |
dc.contributor.author | Pak, Nikita | ko |
dc.contributor.author | Tillberg, Paul W. | ko |
dc.contributor.author | Wassie, Asmamaw T. | ko |
dc.contributor.author | Cai, Dawen | ko |
dc.contributor.author | Boyden, Edward S. | ko |
dc.date.accessioned | 2018-09-18T06:24:48Z | - |
dc.date.available | 2018-09-18T06:24:48Z | - |
dc.date.created | 2018-09-04 | - |
dc.date.created | 2018-09-04 | - |
dc.date.created | 2018-09-04 | - |
dc.date.created | 2018-09-04 | - |
dc.date.created | 2018-09-04 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.citation | NATURE METHODS, v.14, no.6, pp.593 - + | - |
dc.identifier.issn | 1548-7091 | - |
dc.identifier.uri | http://hdl.handle.net/10203/245588 | - |
dc.description.abstract | We recently developed a method called expansion microscopy, in which preserved biological specimens are physically magnified by embedding them in a densely crosslinked polyelectrolyte gel, anchoring key labels or biomolecules to the gel, mechanically homogenizing the specimen, and then swelling the gel-specimen composite by-4.5x in linear dimension. Here we describe iterative expansion microscopy (iExM), in which a sample is expanded-20x. After preliminary expansion a second swellable polymer mesh is formed in the space newly opened up by the first expansion, and the sample is expanded again. iExM expands biological specimens similar to 4.5 x 4.5, or similar to 20x, and enables similar to 25-nm-resolution imaging of cells and tissues on conventional microscopes. We used iExM to visualize synaptic proteins, as well as the detailed architecture of dendritic spines, in mouse brain circuitry. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Iterative expansion microscopy | - |
dc.type | Article | - |
dc.identifier.wosid | 000402291800022 | - |
dc.identifier.scopusid | 2-s2.0-85017506239 | - |
dc.type.rims | ART | - |
dc.citation.volume | 14 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 593 | - |
dc.citation.endingpage | + | - |
dc.citation.publicationname | NATURE METHODS | - |
dc.identifier.doi | 10.1038/NMETH.4261 | - |
dc.contributor.localauthor | Chang, Jae-Byum | - |
dc.contributor.localauthor | Yoon, Young-Gyu | - |
dc.contributor.nonIdAuthor | Chen, Fei | - |
dc.contributor.nonIdAuthor | Jung, Erica E. | - |
dc.contributor.nonIdAuthor | Babcock, Hazen | - |
dc.contributor.nonIdAuthor | Kang, Jeong Seuk | - |
dc.contributor.nonIdAuthor | Asano, Shoh | - |
dc.contributor.nonIdAuthor | Suk, Ho-Jun | - |
dc.contributor.nonIdAuthor | Pak, Nikita | - |
dc.contributor.nonIdAuthor | Tillberg, Paul W. | - |
dc.contributor.nonIdAuthor | Wassie, Asmamaw T. | - |
dc.contributor.nonIdAuthor | Cai, Dawen | - |
dc.contributor.nonIdAuthor | Boyden, Edward S. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | IN-SITU | - |
dc.subject.keywordPlus | FLUORESCENT PROTEINS | - |
dc.subject.keywordPlus | RNA | - |
dc.subject.keywordPlus | LOCALIZATION | - |
dc.subject.keywordPlus | POLYACRYLAMIDE | - |
dc.subject.keywordPlus | FLUOROPHORES | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordPlus | VOLUMES | - |
dc.subject.keywordPlus | TISSUES | - |
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