Chemical biology approaches for studying posttranslational modifications

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Posttranslational modification (PTM) is a key mechanism for regulating diverse protein functions, and thus critically affects many essential biological processes. Critical for systematic study of the effects of PTMs is the ability to obtain recombinant proteins with defined and homogenous modifications. To this end, various synthetic and chemical biology approaches, including genetic code expansion and protein chemical modification methods, have been developed. These methods have proven effective for generating site-specific authentic modifications or structural mimics, and have demonstrated their value for in vitro and in vivo functional studies of diverse PTMs. This review will discuss recent advances in chemical biology strategies and their application to various PTM studies.
Publisher
LANDES BIOSCIENCE
Issue Date
2018-08
Language
English
Article Type
Review
Keywords

SITE-SPECIFIC INCORPORATION; TRANSFER-RNA SYNTHETASES; UNNATURAL AMINO-ACIDS; GENETIC-CODE EXPANSION; ESCHERICHIA-COLI; EPSILON-N; RECOMBINANT HISTONES; MAMMALIAN-CELLS; METHYL-LYSINE; PROTEIN-PHOSPHORYLATION

Citation

RNA BIOLOGY, v.15, no.4-5, pp.427 - 440

ISSN
1547-6286
DOI
10.1080/15476286.2017.1360468
URI
http://hdl.handle.net/10203/245418
Appears in Collection
CH-Journal Papers(저널논문)
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