MEMS devices for drug delivery

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Novel drug delivery systems based on microtechnology have advanced tremendously, but yet face some technological and societal hurdles to fully achieve their potential. The novel drug delivery systems aim to deliver drugs in a spatiotemporal- and dosage-controlled manner with a goal to address the unmet medical needs from oral delivery and hypodermic injection. The unmet needs include effective delivery of new types of drug candidates that are otherwise insoluble and unstable, targeted delivery to areas protected by barriers (e.g. brain and posterior eye segment), localized delivery of potent drugs, and improved patient compliance. After scrutinizing the design considerations and challenges associated with delivery to areas that cannot be efficiently targeted through standard drug delivery (e.g. brain, posterior eye segment, and gastrointestinal tract), this review provides a summary of recent advances that addressed these challenges and summarizes yet unresolved problems in each target area. The opportunities for innovation in devising the novel drug delivery systems are still high; with integration of advanced microtechnology, advanced fabrication of biomaterials, and biotechnology, the novel drug delivery is poised to be a promising alternative to the oral administration and hypodermic injection for a large spectrum of drug candidates.
Publisher
ELSEVIER SCIENCE BV
Issue Date
2018-03
Language
English
Article Type
Review
Keywords

BLOOD-BRAIN-BARRIER; INTENSITY FOCUSED ULTRASOUND; MULTICHANNEL NEURAL PROBE; IN-VIVO; POSTERIOR SEGMENT; INSULIN DELIVERY; CONTROLLED-RELEASE; CAPSULE ENDOSCOPE; VACCINE DELIVERY; ANTISENSE OLIGONUCLEOTIDES

Citation

ADVANCED DRUG DELIVERY REVIEWS, v.128, pp.132 - 147

ISSN
0169-409X
DOI
10.1016/j.addr.2017.11.003
URI
http://hdl.handle.net/10203/244918
Appears in Collection
EE-Journal Papers(저널논문)
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