DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yin, Guo Nan | ko |
dc.contributor.author | Jin, Hai-Rong | ko |
dc.contributor.author | Choi, Min-Ji | ko |
dc.contributor.author | Limanjaya, Anita | ko |
dc.contributor.author | Ghatak, Kalyan | ko |
dc.contributor.author | Nguyen Nhat | ko |
dc.contributor.author | Ock, Jiyeon | ko |
dc.contributor.author | Kwon, Mi-Hye | ko |
dc.contributor.author | Song, Kang-Moon | ko |
dc.contributor.author | Park, Heon Joo | ko |
dc.contributor.author | Kim, Ho Min | ko |
dc.contributor.author | Kwon, Young-Guen | ko |
dc.contributor.author | Ryu, Ji-Kan | ko |
dc.contributor.author | Suh, Jun-Kyu | ko |
dc.date.accessioned | 2018-08-20T07:54:47Z | - |
dc.date.available | 2018-08-20T07:54:47Z | - |
dc.date.created | 2018-08-01 | - |
dc.date.created | 2018-08-01 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.citation | DIABETES, v.67, no.6, pp.1149 - 1161 | - |
dc.identifier.issn | 0012-1797 | - |
dc.identifier.uri | http://hdl.handle.net/10203/244902 | - |
dc.description.abstract | Penile erection requires well-coordinated interactions between vascular and nervous systems. Penile neurovascular dysfunction is amajor cause of erectile dysfunction (ED) in patients with diabetes, which causes poor response to oral phosphodiesterase-5 inhibitors. Dickkopf2 (DKK2), a Wnt antagonist, is known to promote angiogenesis. Here, using DKK2-Tg mice or DKK2 protein administration, we demonstrate that the overexpression of DKK2 in diabetic mice enhances penile angiogenesis and neural regeneration and restores erectile function. Transcriptome analysis revealed that angiopoietin-1 and angiopoietin-2 are target genes for DKK2. Using an endothelial cell-pericyte co-culture system and ex vivo neurite sprouting assay, we found that DKK2-mediated juxtacrine signaling in pericyte-endothelial cell interactions promotes angiogenesis and neural regeneration through an angiopoietin-1-Tie2 pathway, rescuing erectile function in diabetic mice. The dual angiogenic and neurotrophic effects of DKK2, especially as a therapeutic protein, will open new avenues to treating diabetic ED. | - |
dc.language | English | - |
dc.publisher | AMER DIABETES ASSOC | - |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject | RESTORES ERECTILE FUNCTION | - |
dc.subject | MOUSE CORPUS CAVERNOSUM | - |
dc.subject | NEUROTROPHIC FACTOR | - |
dc.subject | SIGNALING PATHWAY | - |
dc.subject | DIABETIC MOUSE | - |
dc.subject | GENE-THERAPY | - |
dc.subject | DYSFUNCTION | - |
dc.subject | CELLS | - |
dc.subject | ANGIOGENESIS | - |
dc.title | Pericyte-Derived Dickkopf2 Regenerates Damaged Penile Neurovasculature Through an Angiopoietin-1-Tie2 Pathway | - |
dc.type | Article | - |
dc.identifier.wosid | 000438781600013 | - |
dc.identifier.scopusid | 2-s2.0-85045567661 | - |
dc.type.rims | ART | - |
dc.citation.volume | 67 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 1149 | - |
dc.citation.endingpage | 1161 | - |
dc.citation.publicationname | DIABETES | - |
dc.identifier.doi | 10.2337/db17-0833 | - |
dc.contributor.localauthor | Kim, Ho Min | - |
dc.contributor.nonIdAuthor | Yin, Guo Nan | - |
dc.contributor.nonIdAuthor | Jin, Hai-Rong | - |
dc.contributor.nonIdAuthor | Choi, Min-Ji | - |
dc.contributor.nonIdAuthor | Limanjaya, Anita | - |
dc.contributor.nonIdAuthor | Ghatak, Kalyan | - |
dc.contributor.nonIdAuthor | Nguyen Nhat | - |
dc.contributor.nonIdAuthor | Ock, Jiyeon | - |
dc.contributor.nonIdAuthor | Kwon, Mi-Hye | - |
dc.contributor.nonIdAuthor | Song, Kang-Moon | - |
dc.contributor.nonIdAuthor | Park, Heon Joo | - |
dc.contributor.nonIdAuthor | Kwon, Young-Guen | - |
dc.contributor.nonIdAuthor | Ryu, Ji-Kan | - |
dc.contributor.nonIdAuthor | Suh, Jun-Kyu | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | RESTORES ERECTILE FUNCTION | - |
dc.subject.keywordPlus | MOUSE CORPUS CAVERNOSUM | - |
dc.subject.keywordPlus | NEUROTROPHIC FACTOR | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | DIABETIC MOUSE | - |
dc.subject.keywordPlus | GENE-THERAPY | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
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