DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jae-Jin | ko |
dc.contributor.author | Kim, Hwang Suk | ko |
dc.contributor.author | Lee, Ji-Sun | ko |
dc.contributor.author | Park, Jimin | ko |
dc.contributor.author | Shin, Sang Chul | ko |
dc.contributor.author | Song, Soonwha | ko |
dc.contributor.author | Lee, Eunsun | ko |
dc.contributor.author | Choi, Jung-Eun | ko |
dc.contributor.author | Suh, Ji-Wan | ko |
dc.contributor.author | Lee, Hongsoo | ko |
dc.contributor.author | Kim, Eunice EunKyeong | ko |
dc.contributor.author | Seo, Eun Kyoung | ko |
dc.contributor.author | Shin, Dong Hae | ko |
dc.contributor.author | Lee, Ho-Young | ko |
dc.contributor.author | Lee, Hee-Yoon | ko |
dc.contributor.author | Lee, Kong-Joo | ko |
dc.date.accessioned | 2018-08-20T07:48:11Z | - |
dc.date.available | 2018-08-20T07:48:11Z | - |
dc.date.created | 2018-08-06 | - |
dc.date.created | 2018-08-06 | - |
dc.date.created | 2018-08-06 | - |
dc.date.created | 2018-08-06 | - |
dc.date.issued | 2018-07 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v.8 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10203/244835 | - |
dc.description.abstract | Nm23-H1/NDPK-A is a tumor metastasis suppressor having NDP kinase (NDPK) activity. Nm23-H1 is positively associated with prolonged disease-free survival and good prognosis of cancer patients. Approaches to increasing the cellular levels of Nm23-H1 therefore have significance in the therapy of metastatic cancers. We found a small molecule, (+/-)-trans-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl] cyclohex-1-ene, that activates Nm23, hereafter called NMac1. NMac1 directly binds to Nm23-H1 and increases its NDPK activity. Employing various NMac1 derivatives and hydrogen/deuterium mass spectrometry (HDX-MS), we identified the pharmacophore and mode of action of NMac1. We found that NMac1 binds to the C-terminal of Nm23-H1 and induces the NDPK activation through its allosteric conformational changes. NMac1-treated MDA-MB-231 breast cancer cells showed dramatic changes in morphology and actin-cytoskeletal organization following inhibition of Rac1 activation. NMac1 also suppressed invasion and migration in vitro, and metastasis in vivo, in a breast cancer mouse model. NMac1 as an activator of NDPK has potential as an anti-metastatic agent. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Small molecule activator of Nm23/NDPK as an inhibitor of metastasis | - |
dc.type | Article | - |
dc.identifier.wosid | 000439101600008 | - |
dc.identifier.scopusid | 2-s2.0-85050625065 | - |
dc.type.rims | ART | - |
dc.citation.volume | 8 | - |
dc.citation.publicationname | SCIENTIFIC REPORTS | - |
dc.identifier.doi | 10.1038/s41598-018-29101-6 | - |
dc.contributor.localauthor | Lee, Hee-Yoon | - |
dc.contributor.nonIdAuthor | Lee, Jae-Jin | - |
dc.contributor.nonIdAuthor | Lee, Ji-Sun | - |
dc.contributor.nonIdAuthor | Park, Jimin | - |
dc.contributor.nonIdAuthor | Shin, Sang Chul | - |
dc.contributor.nonIdAuthor | Song, Soonwha | - |
dc.contributor.nonIdAuthor | Lee, Eunsun | - |
dc.contributor.nonIdAuthor | Choi, Jung-Eun | - |
dc.contributor.nonIdAuthor | Suh, Ji-Wan | - |
dc.contributor.nonIdAuthor | Kim, Eunice EunKyeong | - |
dc.contributor.nonIdAuthor | Seo, Eun Kyoung | - |
dc.contributor.nonIdAuthor | Shin, Dong Hae | - |
dc.contributor.nonIdAuthor | Lee, Ho-Young | - |
dc.contributor.nonIdAuthor | Lee, Kong-Joo | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | NUCLEOSIDE DIPHOSPHATE KINASE | - |
dc.subject.keywordPlus | ZINGIBER-CASSUMUNAR ROXB | - |
dc.subject.keywordPlus | LYMPH-NODE METASTASIS | - |
dc.subject.keywordPlus | MEDROXYPROGESTERONE ACETATE | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | ALLOSTERIC ACTIVATORS | - |
dc.subject.keywordPlus | PHENYLBUTENOID DIMER | - |
dc.subject.keywordPlus | ADHERENS JUNCTIONS | - |
dc.subject.keywordPlus | MASS-SPECTROMETRY | - |
dc.subject.keywordPlus | TUMOR-METASTASIS | - |
dc.subject.keywordPlus | NUCLEOSIDE DIPHOSPHATE KINASE | - |
dc.subject.keywordPlus | ZINGIBER-CASSUMUNAR ROXB | - |
dc.subject.keywordPlus | LYMPH-NODE METASTASIS | - |
dc.subject.keywordPlus | MEDROXYPROGESTERONE ACETATE | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | ALLOSTERIC ACTIVATORS | - |
dc.subject.keywordPlus | PHENYLBUTENOID DIMER | - |
dc.subject.keywordPlus | ADHERENS JUNCTIONS | - |
dc.subject.keywordPlus | MASS-SPECTROMETRY | - |
dc.subject.keywordPlus | TUMOR-METASTASIS | - |
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