Dosimetric characterization and commissioning of a superficial electronic brachytherapy device for skin cancer treatment

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dc.contributor.authorPark, Han Beomko
dc.contributor.authorKim, Hyun Namko
dc.contributor.authorLee, Ju Hyukko
dc.contributor.authorLee, Ik Jaeko
dc.contributor.authorChoi, Jinhyunko
dc.contributor.authorCho, Sung Ohko
dc.date.accessioned2018-08-20T07:47:02Z-
dc.date.available2018-08-20T07:47:02Z-
dc.date.created2018-08-06-
dc.date.created2018-08-06-
dc.date.created2018-08-06-
dc.date.issued2018-08-
dc.identifier.citationNUCLEAR ENGINEERING AND TECHNOLOGY, v.50, no.6, pp.937 - 943-
dc.identifier.issn1738-5733-
dc.identifier.urihttp://hdl.handle.net/10203/244812-
dc.description.abstractBackground: This work presents the performance of a novel electronic brachytherapy (EBT) device and radiotherapy (RT) experiments on both skin cancer cells and animals using the device. Methods and materials: The performance of the EBT device was evaluated by measuring and analyzing the dosimetric characteristics of X-rays generated from the device. The apoptosis of skin cancer cells was analyzed using B16F10 melanoma cancer cells. Animal experiments were performed using C57BL/6 mice. Results: The X-ray characteristics of the EBT device satisfied the accepted tolerance level for RT. The results of the RT experiments on the skin cancer cells show that a significant apoptosis induction occurred after irradiation with 50 kVp X-rays generated from the EBT device. Furthermore, the results of the animal RT experiments demonstrate that the superficial X-rays significantly delay the tumor growth and that the tumor growth delay induced by irradiation with low-energy X-rays was almost the same as that induced by irradiation with a high-energy electron beam. Conclusions: The developed new EBT device has almost the same therapeutic effect on the skin cancer with a conventional linear accelerator. Consequently, the EBT device can be practically used for human skin cancer treatment in the near future. (C) 2018 Korean Nuclear Society, Published by Elsevier Korea LLC.-
dc.languageEnglish-
dc.publisherKOREAN NUCLEAR SOC-
dc.titleDosimetric characterization and commissioning of a superficial electronic brachytherapy device for skin cancer treatment-
dc.typeArticle-
dc.identifier.wosid000439417300017-
dc.identifier.scopusid2-s2.0-85046807158-
dc.type.rimsART-
dc.citation.volume50-
dc.citation.issue6-
dc.citation.beginningpage937-
dc.citation.endingpage943-
dc.citation.publicationnameNUCLEAR ENGINEERING AND TECHNOLOGY-
dc.identifier.doi10.1016/j.net.2018.04.007-
dc.contributor.localauthorCho, Sung Oh-
dc.contributor.nonIdAuthorPark, Han Beom-
dc.contributor.nonIdAuthorLee, Ik Jae-
dc.contributor.nonIdAuthorChoi, Jinhyun-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorCarbon Nanotube-
dc.subject.keywordAuthorElectronic Brachytherapy-
dc.subject.keywordAuthorMiniature X-ray Tube-
dc.subject.keywordAuthorRadiotherapy Experiments-
dc.subject.keywordAuthorSkin Cancer-
dc.subject.keywordPlusRADIATION-THERAPY-
dc.subject.keywordPlusRADIOTHERAPY-
dc.subject.keywordPlusCARCINOMAS-
dc.subject.keywordPlusSURGERY-
dc.subject.keywordPlusPINNA-
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