DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yonghyun | ko |
dc.contributor.author | Lee, Soyoung | ko |
dc.contributor.author | Jon, Sangyong | ko |
dc.date.accessioned | 2018-07-24T02:39:14Z | - |
dc.date.available | 2018-07-24T02:39:14Z | - |
dc.date.created | 2018-07-10 | - |
dc.date.created | 2018-07-10 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.citation | ADVANCED SCIENCE, v.5, no.6 | - |
dc.identifier.issn | 2198-3844 | - |
dc.identifier.uri | http://hdl.handle.net/10203/244297 | - |
dc.description.abstract | The tumor microenvironment (TME) plays a crucial role in tumorigenesis and cancer cell metastasis. Accordingly, a drug-delivery system (DDS) that is capable of targeting tumor and releasing drugs in response to TME-associated stimuli should lead to potent antitumor efficacy. Here, a cancer targeting, reactive oxygen species (ROS)-responsive drug delivery vehicle as an example of a TME-targeting DDS is reported. Tumor targeting is achieved using biotin as a ligand for biotin transporter-overexpressing malignant tumors, and bilirubin-based nanoparticles (BRNPs) are used as a drug-delivery carrier that enables ROS-responsive drug release. Doxorubicin-loaded, biotinylated BRNPs (Dox@bt-BRNPs) with size of approximate to 100 nm are prepared by a one-step self-assembly process. Dox@bt-BRNPs exhibit accelerated Dox-release behavior in response to ROS and show specific binding as well as anticancer activity against biotin transporter-overexpressing HeLa cells in vitro. bt-BRNPs labeled with cypate, near-infrared dye, show much greater accumulation at tumor sites in HeLa tumor-bearing mice than BRNPs lacking the biotin ligand. Finally, intravenous injection of Dox@bt-BRNPs into HeLa tumor-bearing mice results in greater antitumor efficacy compared with free Dox, bt-BRNPs only, and Dox@BRNPs without causing any appreciable body weight loss. Collectively, these findings suggest that bt-BRNPs hold potential as a new TME-responsive DDS for effectively treating various tumors. | - |
dc.language | English | - |
dc.publisher | WILEY | - |
dc.title | Biotinylated Bilirubin Nanoparticles as a Tumor Microenvironment-Responsive Drug Delivery System for Targeted Cancer Therapy | - |
dc.type | Article | - |
dc.identifier.wosid | 000435765900033 | - |
dc.identifier.scopusid | 2-s2.0-85045843813 | - |
dc.type.rims | ART | - |
dc.citation.volume | 5 | - |
dc.citation.issue | 6 | - |
dc.citation.publicationname | ADVANCED SCIENCE | - |
dc.identifier.doi | 10.1002/advs.201800017 | - |
dc.contributor.localauthor | Jon, Sangyong | - |
dc.contributor.nonIdAuthor | Lee, Yonghyun | - |
dc.contributor.nonIdAuthor | Lee, Soyoung | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.