Hippo Signaling Circuit and Divergent Tissue Growth in Mammalian Eye

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Vertebrate organ development is accompanied by demarcation of tissue compartments, which grow coordinately with their neighbors. Hence, perturbing the coordinative growth of neighboring tissue compartments frequently results in organ malformation. The growth of tissue compartments is regulated by multiple intercellular and intracellular signaling pathways, including the Hippo signaling pathway that limits the growth of various organs. In the optic neuroepithelial continuum, which is partitioned into the retina, retinal pigment epithelium (RPE) and ciliary margin (CM) during eye development, the Hippo signaling activity operates differentially, as it does in many tissues. In this review, we summarize recent studies that have explored the relationship between the Hippo signaling pathway and growth of optic neuroepithelial compartments. We will focus particularly on the roles of a tumor suppressor, neurofibromin 2 (NF2), whose expression is not only dependent on compartment-specific transcription factors, but is also subject to regulation by a Hippo-Yap feedback signaling circuit.
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Issue Date
2018-04
Language
English
Article Type
Review
Citation

MOLECULES AND CELLS, v.41, no.4, pp.257 - 263

ISSN
1016-8478
DOI
10.14348/molcells.2018.0091
URI
http://hdl.handle.net/10203/243722
Appears in Collection
BS-Journal Papers(저널논문)
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