Light-Induced Disassembly β-Amyloid Aggregates by Ruthenium Complex = 루테늄 복합체를 이용한 아밀로이드 응집체의 광화학적 분해 연구

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Ruthenium (II) complexes are visible light-active photocatalyst extensively used for solar energy harvesting and conversion applications. Here, we report our finding that tris(2,2-bipyridine) ruthenium(II) $[Ru(bpy)_3^{2+}]$ can function as a highly sensitive, biocompatible agent for anti-amyloidgenesis. The abnormal aggregation of β-amyloid (Aβ) peptides is a major pathological hallmark of Alzheimer's disease. According to our multiple analyses, visible light-induced $Ru(bpy)_3^{2+}$ successfully disassembles preformed Aβ aggregates into non-fibrillar aggregates by destructing β-sheet structures. Moreover, we identified the changes of solubility and diameter of the disassembled A? aggregates and photo-degradation of small oligomers including trimeric, tetrameric species. We also validated that photoexcited $Ru(bpy)_3^{2+}$ can cleave peptide bonds in Aβ using mass spectroscopy. The efficacy of $Ru(bpy)_3^{2+}$ is derived from photon-energy in visible spectrum. $Ru(bpy)_3^{2+}$ generates reactive oxygen species such as singlet oxygen upon absorbing photon energy (λ= 452 nm), resulting in disassembly of Aβ aggregates. Furthermore, photoexcited $Ru(bpy)_3^{2+}$ can reduce in vitro cytotoxicity of Aβ aggregates. Our study advances a new insight of ruthenium (II) complexes as therapeutic agents against AD.
Advisors
Park, Chan Beumresearcher박찬범researcher
Description
한국과학기술원 :신소재공학과,
Publisher
한국과학기술원
Issue Date
2017
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 신소재공학과, 2017.2,[vi, 47 p. :]

Keywords

Ruthenium complex; β-amyloid; aggregates; disassembly; photo-degradation; reactive oxygen species; 루테늄 복합체; 베타 아밀로이드; 응집체; 분해; 광분해; 활성 산소종

URI
http://hdl.handle.net/10203/243136
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=675263&flag=dissertation
Appears in Collection
MS-Theses_Master(석사논문)
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