Engineering of thermo-responsive polymeric hydrogels for fluorescent color switching형광 색상 전환을 위한 열 응답성 고분자 하이드로겔 연구

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Stimuli-responsive hydrogels with decent optical properties are a promising class of polymeric materials for a range of technological applications such as photonic, biomedical and analytical devices due to the high degree of freedom of shapes, portability, and processibility. In this study, we developed a hydrogel-based fluorescent thermometer using organic dyes labeled temperature-responsive copolymer system. Poly(N-isopropylacrylamide) (PNIPAM) was chosen as a thermally-responsive spacer between blue and green emitting dyes in order to make conformational change by temperature, while randomly polymerized acrylates were used to regulate water swelling ratio of the hydrogel. The spatial proximity of F$ddot{o}$rster resonance energy transfer (FRET) between donors and acceptors incorporated in the hydrogel can be tuned via thermo-induced collapsing and swelling of the platform at the lower critical solution temperature of PNIPAM, leading to the facile modulation of FRET efficiencies. In addition, our hydrogel system showed excellent reversibility, indicating an ideal platform for biological and environmental applications.
Advisors
Kim, Bumjoonresearcher김범준researcher
Description
한국과학기술원 :생명화학공학과,
Publisher
한국과학기술원
Issue Date
2017
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명화학공학과, 2017.2,[iii, 44 p. :]

Keywords

hydrogel; FRET; thermo-responsive; PNIPAM; chain conformation; 하이드로겔; 발광 센서; 거리조절; 열 응답성; 포스터 공명 에너지 전달

URI
http://hdl.handle.net/10203/243070
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=675576&flag=dissertation
Appears in Collection
CBE-Theses_Master(석사논문)
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