DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Yi, Gwan Su | - |
dc.contributor.advisor | 이관수 | - |
dc.contributor.author | Kunsic, Nina | - |
dc.date.accessioned | 2018-06-20T06:17:28Z | - |
dc.date.available | 2018-06-20T06:17:28Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=718589&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/242998 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2017.8,[iv, 31 p. :] | - |
dc.description.abstract | Mitochondrial dysfunction was implicated in a diverse set of diseases such as cancer, neurodegenerative disease, cardiovascular disease and metabolic disease. Prior research showed that mitochondria may play a role in onset of obesity or obesity related metabolic complications. I have used three different analysis methods - differential gene expression analysis, differential gene gene correlation and co-expression network based analysis, in order to elucidate possible mechanism connecting mitochondrial function and obesity and to identify mitochondria related obesity markers. This resulted in a set of potential disease markers, which were further tested for their ability to differentiate between obese and non-obese samples by training a random forest classifier and testing it on an independent testing data set. The result of this analysis is a list of 25 mitochondria associated genes showing high importance in obese sample classification, along with a list of 80 genes identified as significant by more than one type of analysis and may therefore represent potential mitochondria associated obesity markers. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Differential gene expression analysis▼adifferential gene-gene correlation▼anetwork analysis▼aclassification▼aobesity▼amitochondrial dysfunction | - |
dc.subject | 차별 유전자 발현 분석▼a차별 유전자 - 유전자 상관 분석▼a네트워크 분석▼a분류▼a비만▼a미토콘드리아 기능 장애 | - |
dc.title | Mitochondria associated markers in obese phenotype inferred from adipose tissue gene expression data | - |
dc.title.alternative | 지방 조직 전사체 데이터 기반 미토콘드리아 연관 세포 표현형 마커 발굴 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :바이오및뇌공학과, | - |
dc.contributor.alternativeauthor | Kunsic Nina Kunsic, Nina | - |
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