Vulnerability analysis of structural brain connectome of subjects with autism spectrum disorder자폐 환자의 구조적 뇌 연결 취약성 분석

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dc.contributor.advisorJeong, Jae Seung-
dc.contributor.advisor정재승-
dc.contributor.authorKim, Su Hyun-
dc.date.accessioned2018-06-20T06:17:22Z-
dc.date.available2018-06-20T06:17:22Z-
dc.date.issued2017-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=718590&flag=dissertationen_US
dc.identifier.urihttp://hdl.handle.net/10203/242991-
dc.description학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2017.8,[iii, 46 p. :]-
dc.description.abstractConnection problems that rise from the alterations of synaptic formation and regulations are hypothesized to the underlying motive of autism spectrum disorders (ASD). Among known functions of autism risk genes, many portion of functions are involved in the production of proteins that regulate the formation of synapses. Here, we present a study that systematically investigated nodal differences of the connectome of subjects with ASD using vulnerability analysis method. We calculated vulnerability index to identify left precuneous cortex, right anterior putamen, left middle temporal gyrus posterior division, and left medial planum temporal as critical nodes that are unique in the ASD group. The identified critical components were well matched with previously known ASD-related brain regions. Also, critical components showed distinct correlations with other graph measures, and this topological characteristics of critical components were well matched with biophysiological functions of critical components. This result suggests that altered regional connectome can be understood in the information flow perspective.-
dc.languageeng-
dc.publisher한국과학기술원-
dc.subjectAutism spectrum disorder▼aComplex network analysis▼aConnectome▼aVulnerability analysis-
dc.subject자폐 스펙트럼 장애▼a네트워크 분석▼a커넥톰▼a취약성 분석-
dc.titleVulnerability analysis of structural brain connectome of subjects with autism spectrum disorder-
dc.title.alternative자폐 환자의 구조적 뇌 연결 취약성 분석-
dc.typeThesis(Master)-
dc.identifier.CNRN325007-
dc.description.department한국과학기술원 :바이오및뇌공학과,-
dc.contributor.alternativeauthor김수현-
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BiS-Theses_Master(석사논문)
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