Vulnerability analysis of structural brain connectome of subjects with autism spectrum disorder = 자폐 환자의 구조적 뇌 연결 취약성 분석

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 330
  • Download : 0
Connection problems that rise from the alterations of synaptic formation and regulations are hypothesized to the underlying motive of autism spectrum disorders (ASD). Among known functions of autism risk genes, many portion of functions are involved in the production of proteins that regulate the formation of synapses. Here, we present a study that systematically investigated nodal differences of the connectome of subjects with ASD using vulnerability analysis method. We calculated vulnerability index to identify left precuneous cortex, right anterior putamen, left middle temporal gyrus posterior division, and left medial planum temporal as critical nodes that are unique in the ASD group. The identified critical components were well matched with previously known ASD-related brain regions. Also, critical components showed distinct correlations with other graph measures, and this topological characteristics of critical components were well matched with biophysiological functions of critical components. This result suggests that altered regional connectome can be understood in the information flow perspective.
Advisors
Jeong, Jae Seungresearcher정재승researcher
Description
한국과학기술원 :바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2017
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2017.8,[iii, 46 p. :]

Keywords

Autism spectrum disorder▼aComplex network analysis▼aConnectome▼aVulnerability analysis; 자폐 스펙트럼 장애▼a네트워크 분석▼a커넥톰▼a취약성 분석

URI
http://hdl.handle.net/10203/242991
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=718590&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0