Surgical suture coated with macrophage targeting polymeric nanoparticles for enhanced anti-inflammatory effect = 항염증 효과를 증대시키기 위한 대식세포 표적 나노입자 코팅 봉합사 개발

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Surgical sutures are essential for most of surgery and treatments for injury. However, sutures elicit foreign body reactions and it leads to excessive inflammatory reactions. The intense inflammation causes inflammatory pain, impediment of wound healing and various wound complications. Traditionally, to manage these adverse events of suture, non-steroidal anti-inflammatory drugs (NSAIDs) are administered by oral route or injection. These administered drugs have low bioavailability and require repetitive administration. Furthermore, systemic exposure of NSAIDs can induce adverse effects. Here, we introduced a new strategy for a functional su-ture having efficient anti-inflammatory effect. We developed anti-inflammatory nanoparticles targeting macro-phages and coated them on the suture. The mannose-PEG nanoparticle showed greater and selective uptake effect for Raw264.7 macrophage cells. It also released diclofenac for about 4 days. These characteristics make nanoparticles to be remained in inflammatory tissues and to sustain release of anti-inflammatory drug. The man-nose-PEG nanoparticle coated suture showed higher anti-inflammatory effect than free diclofenac molecule coated suture. We used advantages of nanoparticles to resolve excessive inflammatory response and it showed significant efficiency compared to free drug molecule. It reveals the potentials of this approach for developing a new functional suture.
Advisors
Park, Ji Horesearcher박지호researcher
Description
한국과학기술원 :바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2015
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2015.8,[vi, 49 p. :]

Keywords

anti-inflammatory; nanoparticle; suture; mannose; macrophage; 항염증; 나노입자; 봉합사; 만노스; 대식세포

URI
http://hdl.handle.net/10203/242969
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=669180&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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